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<table cellspacing="0" cellpadding="0" class="EQ-07">
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<div class="text" style="text-align: justify; font-size: 16px; font-family: 'Lucida Grande'; line-height: 1;"><div style="margin: 0px; line-height: 1;">
<font face="Arial, sans-serif" style="font-size: 14px;"><b>Bonjour à toutes et tous,</b>
</font></div><font face="Arial, sans-serif" style="line-height: 1; font-size: 14px;"><br></font><div style="margin: 0px; line-height: 1;"><font face="Arial, sans-serif" style="font-size: 14px;">L’année se termine et nous avons tous vécu une année 2020 inattendue. Il semble difficile de penser à autre chose que la crise de la COVID 19 qui régit notre vie depuis mars 2020 avec des pauses plus ou moins longues. Je voudrais tout de même profiter de cette newsletter pour évidemment rappeler la nécessité de rester vigilant pendant ces fêtes de fin d’année mais d’emporter avec vous un message d’optimisme pour l’année 2021 qui arrive et qui marquera le début d’un nouveau quinquennat pour le laboratoire. Notre laboratoire sera prochainement renouvelé avec l’ensemble de ses tutelles et toutes nos équipes, comme nous l’avons préparé et souhaité, ont été labélisées par l’Inserm. L’activité et la raison d’être de notre laboratoire demeurent plus que jamais importantes pour maintenir la science à la place qui doit être la sienne. Elle rassemble les disciplines ayant pour objectif commun l’étude de faits et relations vérifiables à laquelle cette newsletter contribue.</font></div><div style="margin: 0px; line-height: 1;"><font face="Arial, sans-serif" style="font-size: 14px;">Joyeuses fêtes et très bonne nouvelle année 2021. </font></div><div style="margin: 0px; line-height: 1;">
<font face="Arial, sans-serif" style="font-size: 14px;">Olivier Beuf
</font></div><div style="margin: 0px;"><br></div><div style="caret-color: rgb(0, 0, 0); font-family: -apple-system, BlinkMacSystemFont, sans-serif; font-size: 14px; text-align: start;"></div><div style="caret-color: rgb(0, 0, 0); font-family: -apple-system, BlinkMacSystemFont, sans-serif; font-size: 14px; text-align: start;"></div></div>
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<font face="Arial, sans-serif" style="font-size: 14px;"><b>Bonjour à toutes et tous,</b>
</font></p></div><font face="Arial, sans-serif" style="line-height: 100%; font-size: 14px;"><br></font><div style="line-height: 100%;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 14px;">L’année se termine et nous avons tous vécu une année 2020 inattendue. Il semble difficile de penser à autre chose que la crise de la COVID 19 qui régit notre vie depuis mars 2020 avec des pauses plus ou moins longues. Je voudrais tout de même profiter de cette newsletter pour évidemment rappeler la nécessité de rester vigilant pendant ces fêtes de fin d’année mais d’emporter avec vous un message d’optimisme pour l’année 2021 qui arrive et qui marquera le début d’un nouveau quinquennat pour le laboratoire. Notre laboratoire sera prochainement renouvelé avec l’ensemble de ses tutelles et toutes nos équipes, comme nous l’avons préparé et souhaité, ont été labélisées par l’Inserm. L’activité et la raison d’être de notre laboratoire demeurent plus que jamais importantes pour maintenir la science à la place qui doit être la sienne. Elle rassemble les disciplines ayant pour objectif commun l’étude de faits et relations vérifiables à laquelle cette newsletter contribue.</font></p></div><div style="line-height: 100%;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 14px;">Joyeuses fêtes et très bonne nouvelle année 2021. </font></p></div><div style="line-height: 100%;"><p style="padding: 0px; margin: 0px;">
<font face="Arial, sans-serif" style="font-size: 14px;">Olivier Beuf
</font></p></div><div style=""><p style="padding: 0px; margin: 0px;"><br></p></div><div style="caret-color: #000000; font-family: sans-serif; font-size: 14px; text-align: start;"></div><div style="caret-color: #000000; font-family: sans-serif; font-size: 14px; text-align: start;"></div></div></td><td style="font-size:1px;" width="10"> </td>
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<table cellspacing="0" cellpadding="0" align="left" class="EQ-05">
<tbody><tr>
<td width="776" valign="top" align="left" background="cid:box-bg-47-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" style="padding-left: 10px; padding-right: 10px;" bgcolor="#ffffff">
<table cellspacing="0" cellpadding="0" class="EQ-07">
<tbody><tr>
<td align="left" class="EQ-05" width="776">
<div class="text" style="font-size: 16px; font-family: 'Lucida Grande'; text-align: left; margin: 0px; line-height: normal;"><b><font face="Arial, sans-serif">ACTUALITE</font></b></div>
</td>
</tr>
</tbody></table>
</td>
</tr>
</tbody></table>
</td>
<td width="10" class="EQ-16"> </td>
</tr>
</tbody></table>
<!--<![endif]--><!--[if gte mso 9]><div style="display:none;"><table cellspacing="0" cellpadding="0" class="EQ-00" width="816">
<tr><td width="10" class="layout-block-padding-left"> </td><td width="796" class="layout-block-content-cell" valign="top" align="left"><v:rect style="width:796px;" stroke="f"><v:fill type="tile" src="cid:box-bg-47-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" color="#ffffff"></v:fill><v:textbox style="mso-fit-shape-to-text:true" inset="0,0,0,0"><div><div style="font-size:0"><table cellspacing="0" cellpadding="0" class="EQ-07">
<tr><td style="font-size:1px;" width="10"> </td><td align="left" class="EQ-05" width="776"><div class="text" style="font-size: 16px; font-family: sans-serif; text-align: left; line-height: normal;"><p style="padding: 0px; margin: 0px;"><b><font face="Arial, sans-serif">ACTUALITE</font></b></p></div></td><td style="font-size:1px;" width="10"> </td>
</tr></table></div></div></v:textbox></v:rect></td><td width="10" class="layout-block-padding-right"> </td>
</tr></table></div><![endif]--></div>
<div width="100%">
<!--[if !mso 15]><!--><table width="816" cellspacing="0" cellpadding="0" class="EQ-00" style="mso-hide:all;">
<tbody><tr>
<td width="10" class="EQ-16"> </td>
<td width="796" class="EQ-18">
<table cellspacing="0" cellpadding="0" align="left" class="EQ-05">
<tbody><tr>
<td width="776" valign="top" align="left" background="cid:box-bg-33-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" style="padding-left: 10px; padding-right: 10px;" bgcolor="#ffffff">
<table cellspacing="0" cellpadding="0" class="EQ-07">
<tbody><tr>
<td align="left" class="EQ-05" width="776">
<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';">
<div style="margin: 0px; line-height: 1;">
</div><div style="text-align: justify; margin: 0px; line-height: 1;">
<font face="Arial, sans-serif" style="font-size: 14px;"><b>Nouveau
projet transversal : COVID-19 </b>
</font></div><div style="margin: 0px; line-height: 1;">
</div><div style="text-align: justify; margin: 0px; line-height: 1;"><font face="Arial, sans-serif" style="font-size: 14px;">Depuis le début de la pandémie COVID-19, radiologues
et médecins de soins intensifs, membres de CREATIS, examinent les patients à
des fins de diagnostic et/ou de choix thérapeutique. Rapidement, un groupe de
chercheurs et personnels d’appui à la recherche s’est également mobilisé pour
contribuer, par des développements en traitement d’images et intelligence
artificielle, à la connaissance de la maladie. Avec l'aide du service
informatique de CREATIS, deux riches bases de données ont été construites et
continuent à se développer à l’hôpital de la Croix Rousse (patients admis en
réanimation avec le syndrome de détresse respiratoire aiguë) et au CHU de Saint
Etienne (patients examinés pour des problèmes respiratoires). Un financement
conjoint par IDEX Université de Lyon, CARE et INS2I-CNRS a permis le
recrutement à CREATIS d’une ingénieure informaticienne, Tiphaine DIOT, en
charge de développement et déploiement de services permettant à la communauté
scientifique française un accès sécurisé aux données du CHU de Saint Etienne. En même
temps, les neuroradiologues du laboratoire, à l'initiative de la Société
française de neuroradiologie (SFNR), ont contribué à la délimitation d'une
large cohorte multicentrique (16 centres cliniques) d'anomalies confirmées des
signaux parenchymateux de l'IRM cérébrale (à l'exclusion des infarctus
ischémiques) chez les patients atteints de COVID-19 sévère.</font></div><div style="text-align: justify; margin: 0px; line-height: 1;"><span style="font-size: 15px;"><font face="Arial, sans-serif"><br></font></span></div>
</div>
</td>
</tr>
</tbody></table>
</td>
</tr>
</tbody></table>
</td>
<td width="10" class="EQ-16"> </td>
</tr>
</tbody></table>
<!--<![endif]--><!--[if gte mso 9]><div style="display:none;"><table cellspacing="0" cellpadding="0" class="EQ-00" width="816">
<tr><td width="10" class="layout-block-padding-left"> </td><td width="796" class="layout-block-content-cell" valign="top" align="left"><v:rect style="width:796px;" stroke="f"><v:fill type="tile" src="cid:box-bg-33-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" color="#ffffff"></v:fill><v:textbox style="mso-fit-shape-to-text:true" inset="0,0,0,0"><div><div style="font-size:0"><table cellspacing="0" cellpadding="0" class="EQ-07">
<tr><td style="font-size:1px;" width="10"> </td><td align="left" class="EQ-05" width="776"><div class="text" style="font-size: 16px; font-family: sans-serif;">
<div style="line-height: 100%;"><p style="padding: 0px; margin: 0px;">
</p></div><div style="text-align: justify; line-height: 100%;"><p style="padding: 0px; margin: 0px;">
<font face="Arial, sans-serif" style="font-size: 14px;"><b>Nouveau
projet transversal : COVID-19 </b>
</font></p></div><div style="line-height: 100%;"><p style="padding: 0px; margin: 0px;">
</p></div><div style="text-align: justify; line-height: 100%;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 14px;">Depuis le début de la pandémie COVID-19, radiologues
et médecins de soins intensifs, membres de CREATIS, examinent les patients à
des fins de diagnostic et/ou de choix thérapeutique. Rapidement, un groupe de
chercheurs et personnels d’appui à la recherche s’est également mobilisé pour
contribuer, par des développements en traitement d’images et intelligence
artificielle, à la connaissance de la maladie. Avec l'aide du service
informatique de CREATIS, deux riches bases de données ont été construites et
continuent à se développer à l’hôpital de la Croix Rousse (patients admis en
réanimation avec le syndrome de détresse respiratoire aiguë) et au CHU de Saint
Etienne (patients examinés pour des problèmes respiratoires). Un financement
conjoint par IDEX Université de Lyon, CARE et INS2I-CNRS a permis le
recrutement à CREATIS d’une ingénieure informaticienne, Tiphaine DIOT, en
charge de développement et déploiement de services permettant à la communauté
scientifique française un accès sécurisé aux données du CHU de Saint Etienne. En même
temps, les neuroradiologues du laboratoire, à l'initiative de la Société
française de neuroradiologie (SFNR), ont contribué à la délimitation d'une
large cohorte multicentrique (16 centres cliniques) d'anomalies confirmées des
signaux parenchymateux de l'IRM cérébrale (à l'exclusion des infarctus
ischémiques) chez les patients atteints de COVID-19 sévère.</font></p></div><div style="text-align: justify; line-height: 100%;"><p style="padding: 0px; margin: 0px;"><span style="font-size: 15px;"><font face="Arial, sans-serif"><br></font></span></p></div>
</div></td><td style="font-size:1px;" width="10"> </td>
</tr></table></div></div></v:textbox></v:rect></td><td width="10" class="layout-block-padding-right"> </td>
</tr></table></div><![endif]--></div>
<div width="100%">
<!--[if !mso 15]><!--><table width="816" cellspacing="0" cellpadding="0" class="EQ-00" style="mso-hide:all;">
<tbody><tr>
<td width="10" class="EQ-16"> </td>
<td width="796" background="cid:box-bg-22-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" class="EQ-18" bgcolor="#ffffff">
<table cellspacing="0" cellpadding="0" align="left" class="EQ-06" width="518">
<tbody><tr>
<td width="518" valign="top" align="left" class="EQ-06">
<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';">
<div style="margin-top: 0px; margin-bottom: 0px; line-height: 1; text-align: justify;"><font face="Arial, sans-serif" style="font-size: 14px;">L'objectif global de ce projet est de développer des méthodes de traitement d'images (principalement basées sur l'intelligence artificielle) pour le diagnostic et le pronostic de COVID-19 ainsi que la compréhension des mécanismes physiopathologiques sous-jacents. En ce qui concerne l'application pulmonaire, l'objectif est de franchir une étape supplémentaire dans la prévision, en particulier pour détecter les patients atteints de COVID-19 grave à un stade précoce, afin de faciliter la gestion de la capacité des unités de soins intensifs. En ce qui concerne l'application neurologique, l'objectif principal est de caractériser les schémas cérébraux de la pathologie et leur corrélation avec les séquelles neurologiques, en particulier chez les patients COVID-19 non graves.</font></div><div style="margin-top: 0px; margin-bottom: 0px; line-height: 1; text-align: justify;"><font face="Arial, sans-serif" style="font-size: 14px;">Le comité de Direction de CREATIS a validé ce nouveau projet transverse le 13 novembre 2020.</font></div><div style="text-align: justify; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 14px;"><br></font></div><div style="text-align: justify; margin: 0px;"><font face="Arial, sans-serif"><i style="font-size: 14px;">Figure: Application de réseaux neuronaux
convolutifs pour extraire le masque de mouvement (en rouge) utilisé dans
l'estimation de la ventilation à partir de paires d'images scanner. Une des
hypothèses de travail du projet est la corrélation entre la répartition
spatiale de la ventilation et l’évolution de la maladie.</i></font>
</div>
</div>
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</tr>
</tbody></table>
<table cellspacing="0" cellpadding="0" align="left" class="layout-block-horizontal-spacer" width="10">
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</tr>
</tbody></table>
<table cellspacing="0" cellpadding="0" align="left" class="EQ-06" width="268">
<tbody><tr>
<td width="268" valign="top" class="EQ-06" align="center">
<div class="layout-block-image">
<img width="268" height="287" alt="" src="cid:image-4-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="display: block; width: 268px; height: 287px;" class="EQ-49"></div>
</td>
</tr>
</tbody></table>
</td>
<td width="10" class="EQ-16"> </td>
</tr>
</tbody></table>
<!--<![endif]--><!--[if gte mso 9]><div style="display:none;"><table cellspacing="0" cellpadding="0" class="EQ-00" width="816">
<tr><td width="10" class="layout-block-padding-left"> </td><td width="796" class="layout-block-content-cell"><v:rect style="width:796px;" stroke="f"><v:fill type="tile" src="cid:box-bg-22-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" color="#ffffff"></v:fill><v:textbox style="mso-fit-shape-to-text:true" inset="0,0,0,0"><div><div style="font-size:0"><table cellspacing="0" cellpadding="0" align="left" class="EQ-06">
<tr><td valign="top" align="left" class="EQ-06" width="518"><div class="text" style="font-size: 16px; font-family: sans-serif;">
<div style="line-height: 100%; text-align: justify;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 14px;">L'objectif global de ce projet est de développer des méthodes de traitement d'images (principalement basées sur l'intelligence artificielle) pour le diagnostic et le pronostic de COVID-19 ainsi que la compréhension des mécanismes physiopathologiques sous-jacents. En ce qui concerne l'application pulmonaire, l'objectif est de franchir une étape supplémentaire dans la prévision, en particulier pour détecter les patients atteints de COVID-19 grave à un stade précoce, afin de faciliter la gestion de la capacité des unités de soins intensifs. En ce qui concerne l'application neurologique, l'objectif principal est de caractériser les schémas cérébraux de la pathologie et leur corrélation avec les séquelles neurologiques, en particulier chez les patients COVID-19 non graves.</font></p></div><div style="line-height: 100%; text-align: justify;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 14px;">Le comité de Direction de CREATIS a validé ce nouveau projet transverse le 13 novembre 2020.</font></p></div><div style="text-align: justify;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 14px;"><br></font></p></div><div style="text-align: justify;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif"><i style="font-size: 14px;">Figure: Application de réseaux neuronaux
convolutifs pour extraire le masque de mouvement (en rouge) utilisé dans
l'estimation de la ventilation à partir de paires d'images scanner. Une des
hypothèses de travail du projet est la corrélation entre la répartition
spatiale de la ventilation et l’évolution de la maladie.</i></font>
</p></div>
</div></td><td class="layout-block-horizontal-spacer" width="10"> </td><td width="268" valign="top" class="EQ-06" align="center"><div class="layout-block-image"><img height="287" alt="" src="cid:image-4-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="display: block;" class="EQ-49" width="268"></img><div style="width:0px;height:0px;max-height:0;max-width:0;overflow:hidden;display:none;visibility:hidden;mso-hide:all;"></div></div></td>
</tr></table></div></div></v:textbox></v:rect></td><td width="10" class="layout-block-padding-right"> </td>
</tr></table></div><![endif]--></div>
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<!--[if !mso 15]><!--><table width="816" cellspacing="0" cellpadding="0" class="EQ-00" style="mso-hide:all;">
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<td width="10" class="EQ-16" style="font-size:1px;"> </td>
<td height="10" background="cid:box-bg-91-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" class="EQ-18" bgcolor="#ffffff" width="796">
<div class="spacer"></div>
</td>
<td width="10" class="EQ-16" style="font-size:1px;"> </td>
</tr>
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<!--<![endif]--><!--[if gte mso 9]><div style="display:none;"><table cellspacing="0" cellpadding="0" class="EQ-00" width="816">
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</tr></table></div><![endif]--></div>
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<!--[if !mso 15]><!--><table width="816" cellspacing="0" cellpadding="0" class="EQ-00" style="mso-hide:all;">
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<td width="796" class="EQ-18">
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<td width="776" valign="top" align="left" background="cid:box-bg-73-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" style="padding-left: 10px; padding-right: 10px;" bgcolor="#ffffff">
<table cellspacing="0" cellpadding="0" class="EQ-07">
<tbody><tr>
<td align="left" class="EQ-05" width="776">
<div class="text" style="font-size: 16px; font-family: 'Lucida Grande'; text-align: justify; line-height: 1.5;">
<font style="line-height: 1.5;" face="Arial, sans-serif"><b>VALORISATION</b></font></div>
</td>
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</tbody></table>
</td>
</tr>
</tbody></table>
</td>
<td width="10" class="EQ-16"> </td>
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<!--<![endif]--><!--[if gte mso 9]><div style="display:none;"><table cellspacing="0" cellpadding="0" class="EQ-00" width="816">
<tr><td width="10" class="layout-block-padding-left"> </td><td width="796" class="layout-block-content-cell" valign="top" align="left"><v:rect style="width:796px;" stroke="f"><v:fill type="tile" src="cid:box-bg-73-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" color="#ffffff"></v:fill><v:textbox style="mso-fit-shape-to-text:true" inset="0,0,0,0"><div><div style="font-size:0"><table cellspacing="0" cellpadding="0" class="EQ-07">
<tr><td style="font-size:1px;" width="10"> </td><td align="left" class="EQ-05" width="776"><div class="text" style="font-size: 16px; font-family: sans-serif; text-align: justify; line-height: 150%;">
<font style="line-height: 150%;" face="Arial, sans-serif"><b>VALORISATION</b></font></div></td><td style="font-size:1px;" width="10"> </td>
</tr></table></div></div></v:textbox></v:rect></td><td width="10" class="layout-block-padding-right"> </td>
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<!--[if !mso 15]><!--><table width="816" cellspacing="0" cellpadding="0" class="EQ-00" style="mso-hide:all;">
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<td width="10"> </td>
<td width="796" background="cid:box-bg-73-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" bgcolor="#ffffff">
<table cellspacing="0" cellpadding="0" align="left" class="EQ-06" width="127">
<tbody><tr>
<td width="127" valign="top" class="EQ-06" align="center">
<div class="layout-block-image">
<img width="127" height="131" alt="" src="cid:image-17-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="line-height: 1px; display: block; width: 127px; height: 131px;"></div>
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</tr>
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<table cellspacing="0" cellpadding="0" align="left" class="EQ-06" width="659">
<tbody><tr>
<td width="659" valign="top" align="left" class="EQ-06">
<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';">
<div style="margin: 0px;">
</div><div style="margin: 0px; text-align: justify;"><font face="Arial, sans-serif" style="font-size: 14px;"><b>Charly Caredda</b> a effectué sa thèse à <b>CREATIS</b> en imagerie optique sous l'encadrement de Bruno Montcel et de Raphaël Sablong. Son travail qui a été plusieurs fois primé, portait sur le développment d'un système temps réel pour l'imagerie cérébrale fonctionnelle interventionnelle réalisée à l'aide d'une caméra RGB. Il est recruté par <b><a href="http://p4l0.mj.am/nl2/p4l0/mhr4v.html?m=AUoAABpYj3EAAcnIvbwAAGW_CKQAAP__82AAGoCWAANvgABf23CMlooHvQ1oRKaIoe8IP7SKEAADSjg&b=09d198df&e=9fcdfbf3&x=xAQRVZzgOLx0vmbW0hPzgFMs3lIflEFV22tNJOgd7VI"><b>Pulsalys</b></a></b>, la <b>SATT</b> (Société d'Accélération du Transfert de Technologie de l’Université Claude bernard, Lyon1) pour une durée d'un an et hébergé à <b>CREATIS</b>. L'objectif de son contrat est de valoriser ses résultats de thèse en neuroimagerie fonctionnelle interventionnelle en vue d'un transfert technologique auprès des principaux acteurs industriels spécialisés dans la conception de dispositifs optiques pour l'aide à la neurochirurgie.</font></div><div style="margin: 0px;">
</div><div style="margin: 0px;">
</div>
</div>
</td>
</tr>
</tbody></table>
</td>
<td width="10"> </td>
</tr>
</tbody></table>
<!--<![endif]--><!--[if gte mso 9]><div style="display:none;"><table cellspacing="0" cellpadding="0" class="EQ-00" width="816">
<tr><td width="10" class="layout-block-padding-left"> </td><td width="796" class="layout-block-content-cell"><v:rect style="width:796px;" stroke="f"><v:fill type="tile" src="cid:box-bg-73-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" color="#ffffff"></v:fill><v:textbox style="mso-fit-shape-to-text:true" inset="0,0,0,0"><div><div style="font-size:0"><table cellspacing="0" cellpadding="0" align="left" class="EQ-06">
<tr><td valign="top" class="EQ-06" align="center" width="127"><div class="layout-block-image"><img height="131" alt="" src="cid:image-17-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="line-height: 1px; display: block;" class="" width="127"></img><div style="width:0px;height:0px;max-height:0;max-width:0;overflow:hidden;display:none;visibility:hidden;mso-hide:all;"></div></div></td><td class="layout-block-horizontal-spacer" width="10"> </td><td width="659" valign="top" align="left" class="EQ-06"><div class="text" style="font-size: 16px; font-family: sans-serif;">
<div style=""><p style="padding: 0px; margin: 0px;">
</p></div><div style="text-align: justify;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 14px;"><b>Charly Caredda</b> a effectué sa thèse à <b>CREATIS</b> en imagerie optique sous l'encadrement de Bruno Montcel et de Raphaël Sablong. Son travail qui a été plusieurs fois primé, portait sur le développment d'un système temps réel pour l'imagerie cérébrale fonctionnelle interventionnelle réalisée à l'aide d'une caméra RGB. Il est recruté par <b><a href="http://p4l0.mj.am/nl2/p4l0/mhr4v.html?m=AUoAABpYj3EAAcnIvbwAAGW_CKQAAP__82AAGoCWAANvgABf23CMlooHvQ1oRKaIoe8IP7SKEAADSjg&b=09d198df&e=9fcdfbf3&x=xAQRVZzgOLx0vmbW0hPzgFMs3lIflEFV22tNJOgd7VI"><b>Pulsalys</b></a></b>, la <b>SATT</b> (Société d'Accélération du Transfert de Technologie de l’Université Claude bernard, Lyon1) pour une durée d'un an et hébergé à <b>CREATIS</b>. L'objectif de son contrat est de valoriser ses résultats de thèse en neuroimagerie fonctionnelle interventionnelle en vue d'un transfert technologique auprès des principaux acteurs industriels spécialisés dans la conception de dispositifs optiques pour l'aide à la neurochirurgie.</font></p></div><div style=""><p style="padding: 0px; margin: 0px;">
</p></div><div style=""><p style="padding: 0px; margin: 0px;">
</p></div>
</div></td>
</tr></table></div></div></v:textbox></v:rect></td><td width="10" class="layout-block-padding-right"> </td>
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<img width="355" height="366" alt="" src="cid:image-14-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="line-height: 1px; display: none; max-height: 0px; overflow: hidden; width: 355px; height: 366px;" class="EQ-11"></div>
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</div><div style="margin: 0px; text-align: justify;"><font face="Arial, sans-serif" style="font-size: 14px;"><b>Charly Caredda</b> a effectué sa thèse à <b>CREATIS</b> en imagerie optique sous l'encadrement de Bruno Montcel et de Raphaël Sablong. Son travail qui a été plusieurs fois primé, portait sur le développment d'un système temps réel pour l'imagerie cérébrale fonctionnelle interventionnelle réalisée à l'aide d'une caméra RGB. Il est recruté par <b><a href="http://p4l0.mj.am/nl2/p4l0/mhr4v.html?m=AUoAABpYj3EAAcnIvbwAAGW_CKQAAP__82AAGoCWAANvgABf23CMlooHvQ1oRKaIoe8IP7SKEAADSjg&b=09d198df&e=9fcdfbf3&x=xAQRVZzgOLx0vmbW0hPzgFMs3lIflEFV22tNJOgd7VI"><b>Pulsalys</b></a></b>, la <b>SATT</b> (Société d'Accélération du Transfert de Technologie de l’Université Claude bernard, Lyon1) pour une durée d'un an et hébergé à <b>CREATIS</b>. L'objectif de son contrat est de valoriser ses résultats de thèse en neuroimagerie fonctionnelle interventionnelle en vue d'un transfert technologique auprès des principaux acteurs industriels spécialisés dans la conception de dispositifs optiques pour l'aide à la neurochirurgie.</font></div><div style="margin: 0px;">
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande'; text-align: left; margin: 0px; line-height: normal;"><b><font face="Arial, sans-serif">PRIX, PROMOTIONS, CONCOURS</font></b></div>
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande'; text-align: left; margin: 0px; line-height: normal;"><b style="font-family: Arial;">Habilitation à Diriger des Recherches </b><font face="Arial, sans-serif"><b>(HDR): Damien GARCIA, HDR, Chargé de Recherche INSERM</b></font></div>
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<tr><td style="font-size:1px;" width="10"> </td><td align="left" class="EQ-05" width="776"><div class="text" style="font-size: 16px; font-family: sans-serif; text-align: left; line-height: normal;"><p style="padding: 0px; margin: 0px;"><b style="font-family: Arial;">Habilitation à Diriger des Recherches </b><font face="Arial, sans-serif"><b>(HDR): Damien GARCIA, HDR, Chargé de Recherche INSERM</b></font></p></div></td><td style="font-size:1px;" width="10"> </td>
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<table cellspacing="0" cellpadding="0" align="left" class="EQ-06" width="238">
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<img width="238" height="273" alt="" src="cid:image-11-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="display: block; width: 238px; height: 273px;" class="EQ-66"></div>
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande'; line-height: normal; border-collapse: collapse;"><div style="font-size: 16px; text-align: justify; margin-top: 0px; margin-bottom: 0px;"><font style="font-size: 14px;" face="Arial, sans-serif"><b>Damien Garcia</b> a été recruté comme chargé de recherche INSERM, en décembre 2017, à <b>CREATIS</b>. Ses travaux de recherche sont centrés sur <b>l’étude de l'hémodynamique cardiaque pour laquelle il développe des modèles biomécaniques et des modalités échocardiographiques pour l’application clinique</b>. Il a obtenu son HDR le 7 juillet 2020. En vertu de l’article 1 de l’arrêté du 23 novembre 1988 relatif à l'HDR, il a alors été jugé apte à diriger, en France, les recherches qu'il menait auparavant au Canada. Le jury, incluant cardiologue, biomécanicienne, et ultrasoneux, fut le suivant : </font></div><table class="EQL-02" style="font-size: 16px; margin-left: 5px;"><tbody><tr><th style="width: 25px; padding-top: 0px; padding-bottom: 0px; line-height: 0;"></th></tr><tr><td class="EQL-00" align="right" valign="top" style="font-size: 16px;">●</td><td class="EQL-01" style="font-size: 16px;"><font style="font-size: 14px;" face="Arial, sans-serif"><span style="line-height: normal;"><a href="https://scholar.google.com/citations?user=nnmHFMgAAAAJ"><span style="line-height: normal; color: rgb(220, 161, 13);">Erwan Donal</span></a></span>, Professeur des Universités - Praticien Hospitalier, rapporteur</font></td></tr><tr><td class="EQL-00" align="right" valign="top" style="font-size: 16px;">●</td><td class="EQL-01" style="font-size: 16px;"><font style="font-size: 14px;" face="Arial, sans-serif"><span style="line-height: normal;"><a href="https://scholar.google.com/citations?user=xzCDWpkAAAAJ"><span style="line-height: normal; color: rgb(220, 161, 13);">Mickaël Tanter</span></a></span>, Directeur de Recherche INSERM, rapporteur</font></td></tr><tr><td class="EQL-00" align="right" valign="top" style="font-size: 16px;">●</td><td class="EQL-01" style="font-size: 16px;"><font style="font-size: 14px;" face="Arial, sans-serif"><span style="line-height: normal;"><a href="https://scholar.google.com/citations?user=qUznTGcAAAAJ"><span style="line-height: normal; color: rgb(220, 161, 13);">Irène Vignon-Clémentel</span></a></span>, Directeur de Recherche INRIA, rapporteur</font></td></tr><tr><td class="EQL-00" align="right" valign="top" style="font-size: 16px;">●</td><td class="EQL-01" style="font-size: 16px;"><font style="font-size: 14px;" face="Arial, sans-serif"><span style="line-height: normal;"><a href="http://labtau.univ-lyon1.fr/members/lafon-cyril"><span style="line-height: normal; color: rgb(220, 161, 13);">Cyril Lafon</span></a></span>, Directeur de Recherche INSERM, examinateur</font></td></tr><tr><td class="EQL-00" align="right" valign="top" style="font-size: 16px;">●</td><td class="EQL-01" style="font-size: 16px;"><font style="font-size: 14px;" face="Arial, sans-serif"><span style="line-height: normal;"><a href="https://scholar.google.com/citations?user=y_pfbKQAAAAJ"><span style="line-height: normal; color: rgb(220, 161, 13);">Hervé Liebgott</span></a></span>, Professeur des Universités, examinateur</font></td></tr></tbody></table><div style="font-size: 16px; text-align: justify; margin-top: 0px; margin-bottom: 0px;"><font style="font-size: 14px;" face="Arial, sans-serif"><br></font></div><div style="font-size: 16px; text-align: justify; line-height: 1;"></div><div style="font-size: 16px; text-align: justify; margin-top: 0px; margin-bottom: 0px;"><font style="font-size: 14px;" face="Arial, sans-serif">Pour les curieuses et curieux, le mémoire d'HDR de Damien est disponible <a href="http://www.biomecardio.com/files/HDR_DG19.pdf"><span style="color: rgb(220, 161, 13);">ici</span></a>.</font></div><br></div>
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<tr><td valign="top" class="EQ-06" align="center" width="238"><div class="layout-block-image"><img height="273" alt="" src="cid:image-11-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="display: block;" class="EQ-66" width="238"></img><div style="width:0px;height:0px;max-height:0;max-width:0;overflow:hidden;display:none;visibility:hidden;mso-hide:all;"></div></div></td><td class="layout-block-horizontal-spacer" width="10"> </td><td width="548" valign="top" align="left" class="EQ-06"><div class="text" style="font-size: 16px; font-family: sans-serif; line-height: normal; border-collapse: collapse;"><div style="font-size: 16px; text-align: justify;"><p style="padding: 0px; margin: 0px;"><font style="font-size: 14px;" face="Arial, sans-serif"><b>Damien Garcia</b> a été recruté comme chargé de recherche INSERM, en décembre 2017, à <b>CREATIS</b>. Ses travaux de recherche sont centrés sur <b>l’étude de l'hémodynamique cardiaque pour laquelle il développe des modèles biomécaniques et des modalités échocardiographiques pour l’application clinique</b>. Il a obtenu son HDR le 7 juillet 2020. En vertu de l’article 1 de l’arrêté du 23 novembre 1988 relatif à l'HDR, il a alors été jugé apte à diriger, en France, les recherches qu'il menait auparavant au Canada. Le jury, incluant cardiologue, biomécanicienne, et ultrasoneux, fut le suivant : </font></p></div><table class="EQL-02" style="font-size: 16px; margin-left: 5px;"><tbody><tr><th style="width: 25px; padding-top: 0px; padding-bottom: 0px; line-height: 0%;"></th></tr><tr><td class="EQL-00" align="right" valign="top" style="font-size: 16px;">●</td><td class="EQL-01" style="font-size: 16px;"><font style="font-size: 14px;" face="Arial, sans-serif"><span style="line-height: normal;"><a href="https://scholar.google.com/citations?user=nnmHFMgAAAAJ"><span style="line-height: normal; color: #DCA10D;">Erwan Donal</span></a></span>, Professeur des Universités - Praticien Hospitalier, rapporteur</font></td></tr><tr><td class="EQL-00" align="right" valign="top" style="font-size: 16px;">●</td><td class="EQL-01" style="font-size: 16px;"><font style="font-size: 14px;" face="Arial, sans-serif"><span style="line-height: normal;"><a href="https://scholar.google.com/citations?user=xzCDWpkAAAAJ"><span style="line-height: normal; color: #DCA10D;">Mickaël Tanter</span></a></span>, Directeur de Recherche INSERM, rapporteur</font></td></tr><tr><td class="EQL-00" align="right" valign="top" style="font-size: 16px;">●</td><td class="EQL-01" style="font-size: 16px;"><font style="font-size: 14px;" face="Arial, sans-serif"><span style="line-height: normal;"><a href="https://scholar.google.com/citations?user=qUznTGcAAAAJ"><span style="line-height: normal; color: #DCA10D;">Irène Vignon-Clémentel</span></a></span>, Directeur de Recherche INRIA, rapporteur</font></td></tr><tr><td class="EQL-00" align="right" valign="top" style="font-size: 16px;">●</td><td class="EQL-01" style="font-size: 16px;"><font style="font-size: 14px;" face="Arial, sans-serif"><span style="line-height: normal;"><a href="http://labtau.univ-lyon1.fr/members/lafon-cyril"><span style="line-height: normal; color: #DCA10D;">Cyril Lafon</span></a></span>, Directeur de Recherche INSERM, examinateur</font></td></tr><tr><td class="EQL-00" align="right" valign="top" style="font-size: 16px;">●</td><td class="EQL-01" style="font-size: 16px;"><font style="font-size: 14px;" face="Arial, sans-serif"><span style="line-height: normal;"><a href="https://scholar.google.com/citations?user=y_pfbKQAAAAJ"><span style="line-height: normal; color: #DCA10D;">Hervé Liebgott</span></a></span>, Professeur des Universités, examinateur</font></td></tr></tbody></table><div style="font-size: 16px; text-align: justify;"><p style="padding: 0px; margin: 0px;"><font style="font-size: 14px;" face="Arial, sans-serif"><br></font></p></div><div style="font-size: 16px; text-align: justify; line-height: 100%;"></div><div style="font-size: 16px; text-align: justify;"><p style="padding: 0px; margin: 0px;"><font style="font-size: 14px;" face="Arial, sans-serif">Pour les curieuses et curieux, le mémoire d'HDR de Damien est disponible <a href="http://www.biomecardio.com/files/HDR_DG19.pdf"><span style="color: #DCA10D;">ici</span></a>.</font></p></div><br></div></td>
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';"><div style="margin-top: 0px; margin-bottom: 0px; line-height: inherit; text-align: justify;"><font face="Arial, sans-serif"><b style="font-size: 15px;"><a href="https://www.mdpi.com/2076-3417/10/15/5158#cite">Optimal Spectral Combination of a Hyperspectral Camera for Intraoperative Hemodynamic and Metabolic Brain Mapping</a>. </b><span style="font-size: 15px;"><b>Charly Caredda, Laurent Mahieu-Williame, Raphaël Sablong, Michaël Sdika, Jacques Guyotat and Bruno Montcel.</b> </span></font><span style="font-family: Arial, sans-serif; font-size: 15px;"><span style="font-style: italic; line-height: inherit; color: rgb(34, 34, 34); text-align: start;">Appl. Sci.</span><span style="color: rgb(34, 34, 34); text-align: start;"> </span><span style="line-height: inherit; color: rgb(34, 34, 34); text-align: start;">2020</span><span style="color: rgb(34, 34, 34); text-align: start;">, </span><span style="font-style: italic; line-height: inherit; color: rgb(34, 34, 34); text-align: start;">10</span><span style="color: rgb(34, 34, 34); text-align: start;">(15), 5158; </span></span></div><div style="margin-top: 0px; margin-bottom: 0px; line-height: inherit; text-align: justify;"><font face="Arial, sans-serif"><span style="font-size: 15px;"><br></span></font></div></div>
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<tr><td style="font-size:1px;" width="10"> </td><td align="left" class="EQ-05" width="776"><div class="text" style="font-size: 16px; font-family: sans-serif;"><div style="line-height: inherit; text-align: justify;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif"><b style="font-size: 15px;"><a href="https://www.mdpi.com/2076-3417/10/15/5158#cite">Optimal Spectral Combination of a Hyperspectral Camera for Intraoperative Hemodynamic and Metabolic Brain Mapping</a>. </b><span style="font-size: 15px;"><b>Charly Caredda, Laurent Mahieu-Williame, Raphaël Sablong, Michaël Sdika, Jacques Guyotat and Bruno Montcel.</b> </span></font><span style="font-family: Arial, sans-serif; font-size: 15px;"><span style="font-style: italic; line-height: inherit; color: #222222; text-align: start;">Appl. Sci.</span><span style="color: #222222; text-align: start;"> </span><span style="line-height: inherit; color: #222222; text-align: start;">2020</span><span style="color: #222222; text-align: start;">, </span><span style="font-style: italic; line-height: inherit; color: #222222; text-align: start;">10</span><span style="color: #222222; text-align: start;">(15), 5158; </span></span></p></div><div style="line-height: inherit; text-align: justify;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif"><span style="font-size: 15px;"><br></span></font></p></div></div></td><td style="font-size:1px;" width="10"> </td>
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<div style="margin: 0px; line-height: inherit;"></div><div style="margin: 0px;"><span style="font-size: 14px;"><font face="Arial, sans-serif">Intraoperative optical imaging is a localization technique for the functional areas of the human brain cortex during neurosurgical procedures. These areas are assessed by monitoring the oxygenated (HbO 2 ) and deoxygenated hemoglobin (Hb) concentration changes occurring in the brain. Sometimes, the functional status of the brain is assessed using metabolic biomarkers: the oxidative state of cytochrome-c-oxidase (oxCCO). A setup composed of a white light source and a hyperspectral or a standard RGB camera could be used to identify the functional areas. The choice of the best spectral configuration is still based on an empirical approach. We propose in this study a method to define the optimal spectral combinations of a commercial hyperspectral camera for the computation of hemodynamic and metabolic brain maps. The method is based on a Monte Carlo framework that simulates the acquisition of the intrinsic optical signal following a neuronal activation. The results indicate that the optimal spectral combination of a hyperspectral camera aims to accurately quantify the HbO 2 (0.5% error), Hb (4.4% error), and oxCCO (15% error) responses in the brain following neuronal activation. We also show that RGB imaging is a low cost and accurate solution to compute Hb maps (4% error), but not accurate to compute HbO 2 (48% error) or oxCCO (1036% error) maps.</font></span></div><div style="text-align: justify; margin: 0px 0px 8px; line-height: 1; color: rgb(0, 0, 0);"><br></div>
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<div style="line-height: inherit;"><p style="padding: 0px; margin: 0px;"></p></div><div style=""><p style="padding: 0px; margin: 0px;"><span style="font-size: 14px;"><font face="Arial, sans-serif">Intraoperative optical imaging is a localization technique for the functional areas of the human brain cortex during neurosurgical procedures. These areas are assessed by monitoring the oxygenated (HbO 2 ) and deoxygenated hemoglobin (Hb) concentration changes occurring in the brain. Sometimes, the functional status of the brain is assessed using metabolic biomarkers: the oxidative state of cytochrome-c-oxidase (oxCCO). A setup composed of a white light source and a hyperspectral or a standard RGB camera could be used to identify the functional areas. The choice of the best spectral configuration is still based on an empirical approach. We propose in this study a method to define the optimal spectral combinations of a commercial hyperspectral camera for the computation of hemodynamic and metabolic brain maps. The method is based on a Monte Carlo framework that simulates the acquisition of the intrinsic optical signal following a neuronal activation. The results indicate that the optimal spectral combination of a hyperspectral camera aims to accurately quantify the HbO 2 (0.5% error), Hb (4.4% error), and oxCCO (15% error) responses in the brain following neuronal activation. We also show that RGB imaging is a low cost and accurate solution to compute Hb maps (4% error), but not accurate to compute HbO 2 (48% error) or oxCCO (1036% error) maps.</font></span></p></div><div style="text-align: justify; line-height: 100%; color: #000000;"><p style="padding: 0px; margin: 0px 0px 8px;"><br></p></div>
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';"><font face="Arial"><i style="font-size: 14px;"><b>Figure: </b>Images obtained in a 69-year-old patients 7 days after percutaneous coronary intervention with an inferolateral marginal occlusion and an inferolatera lesion with a large no-reflow lesion.</i></font></div>
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<tr><td width="140" valign="top" align="left" class="EQ-06" style="padding-left:10px;"><div class="text" style="font-size: 16px; font-family: sans-serif;"><font face="Arial"><i style="font-size: 14px;"><b>Figure: </b>Images obtained in a 69-year-old patients 7 days after percutaneous coronary intervention with an inferolateral marginal occlusion and an inferolatera lesion with a large no-reflow lesion.</i></font></div></td><td class="layout-block-3-columns spacer" width="10"> </td><td width="626" valign="top" class="layout-block-3-columns full-width" align="center" style="padding-right:10px;"><div class="layout-block-image"><img height="347" alt="" src="cid:image-16-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="padding-right: 0px; display: block;" class="" width="626"></img><div style="width:0px;height:0px;max-height:0;max-width:0;overflow:hidden;display:none;visibility:hidden;mso-hide:all;"></div></div></td>
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';"><i style="font-family: Arial; font-size: 14px;"><b>Figure: </b>Images obtained in a 69-year-old patients 7 days after percutaneous coronary intervention with an inferolateral marginal occlusion and an inferolatera lesion with a large no-reflow lesion.</i></div>
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<td width="776" valign="top" align="left" background="cid:box-bg-33-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" style="padding-left: 10px; padding-right: 10px;" bgcolor="#ffffff">
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';"><div style="margin-top: 0px; margin-bottom: 0px; text-align: justify; line-height: 1.2;"><font face="Arial, sans-serif"><a href="https://journals.lww.com/acsm-msse/Abstract/9000/Quantitative_Magnetic_Resonance_Imaging_Assessment.96169.aspx" style="font-size: 15px; color: rgb(0, 58, 255); text-decoration: none;"><b>Quantitative Magnetic Resonance Imaging Assessment of the Quadriceps Changes during an Extreme Mountain Ultramarathon.</b></a> <span style="font-size: 15px; text-align: start; color: rgb(33, 33, 33);"><b>Nguyen HT, Grenier T, Leporq B, Le Goff C, Gilles B, Grange S, Grange R, Millet GP, Beuf O, Croisille P, Viallon M.</b> </span><span style="text-align: start; font-size: 15px;">Med Sci Sports Exerc.<b> </b>2020 Oct 7. PMID: 33044438. </span></font></div><div style="margin-top: 0px; margin-bottom: 0px; line-height: inherit; text-align: justify;"><font face="Arial, sans-serif" style="font-size: 15px;"><br></font></div></div>
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<tr><td style="font-size:1px;" width="10"> </td><td align="left" class="EQ-05" width="776"><div class="text" style="font-size: 16px; font-family: sans-serif;"><div style="text-align: justify; line-height: 120%;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif"><a href="https://journals.lww.com/acsm-msse/Abstract/9000/Quantitative_Magnetic_Resonance_Imaging_Assessment.96169.aspx" style="font-size: 15px; color: #003AFF; text-decoration: none;"><b>Quantitative Magnetic Resonance Imaging Assessment of the Quadriceps Changes during an Extreme Mountain Ultramarathon.</b></a> <span style="font-size: 15px; text-align: start; color: #212121;"><b>Nguyen HT, Grenier T, Leporq B, Le Goff C, Gilles B, Grange S, Grange R, Millet GP, Beuf O, Croisille P, Viallon M.</b> </span><span style="text-align: start; font-size: 15px;">Med Sci Sports Exerc.<b> </b>2020 Oct 7. PMID: 33044438. </span></font></p></div><div style="line-height: inherit; text-align: justify;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 15px;"><br></font></p></div></div></td><td style="font-size:1px;" width="10"> </td>
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<div style="margin: 0px; line-height: inherit;"></div><div style="margin: 0px;"><span style="font-family: Arial, sans-serif; font-size: 14px;">Extreme ultra-endurance races are growing in popularity but their effects on skeletal muscles remain mostly unexplored. This longitudinal study explores physiological changes in mountain ultramarathon (MUM) athletes’ quadriceps using quantitative magnetic resonance imaging (qMRI) coupled with serological biomarkers. </span></div><div style="margin: 0px;"><span style="font-family: Arial, sans-serif; font-size: 14px;">The study aimed to monitor the longitudinal effect of the race and recovery, and to identify local inflammatory and metabolic muscle responses by codetection of biological markers. </span><span style="font-family: Arial, sans-serif; font-size: 14px; color: rgb(53, 53, 53);">An automatic image processing framework was designed to extract imaging-based biomarkers from qMRI acquisitions of the upper legs of 20 finishers at three time points. The longitudinal impact of the race was demonstrated by analyzing the image markers with dedicated biostatistical analysis. </span></div><div style="margin: 0px;"><span style="font-family: Arial, sans-serif; font-size: 14px; color: rgb(53, 53, 53);">Our framework allows a reliable calculation of statistical data not only inside the whole quadriceps volume but also within each individual muscle heads. Local changes in MRI parameters extracted from quantitative maps were described and found significantly correlated with principal serological biomarkers of interest. A decrease in the PDFF after the race and a stable paramagnetic susceptibility value were found. Pairwise post hoc tests suggested that the recovery process differs among the muscle heads.</span></div><div style="margin: 0px;"><span style="font-size: 14px;"><font face="Arial, sans-serif">This longitudinal study conducted during a prolonged and extreme mechanical stress, showed that quantitative MRI-based markers of inflammation and metabolic response can detect local changes related to the prolonged exercise, with differentiated involvement of each head of the quadriceps muscle as expected in such eccentric load. Consistent and efficient extraction of the local biomarkers enables to highlight interplay/interactions between blood and MRI biomarkers. This work indeed proposes an automatized analytic framework to tackle the time consuming and mentally exhausting segmentation task of muscle heads in large multi-time-points cohorts.</font></span></div>
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<tr><td width="10" class="layout-block-padding-left"> </td><td width="796" class="layout-block-content-cell" valign="top" align="left"><v:rect style="width:796px;" stroke="f"><v:fill type="tile" src="cid:box-bg-33-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" color="#ffffff"></v:fill><v:textbox style="mso-fit-shape-to-text:true" inset="0,0,0,0"><div><div style="font-size:0"><table cellspacing="0" cellpadding="0" class="EQ-07">
<tr><td style="font-size:1px;" width="10"> </td><td align="left" class="EQ-05" width="776"><div class="text" style="text-align: justify; font-size: 16px; font-family: sans-serif;">
<div style="line-height: inherit;"><p style="padding: 0px; margin: 0px;"></p></div><div style=""><p style="padding: 0px; margin: 0px;"><span style="font-family: Arial, sans-serif; font-size: 14px;">Extreme ultra-endurance races are growing in popularity but their effects on skeletal muscles remain mostly unexplored. This longitudinal study explores physiological changes in mountain ultramarathon (MUM) athletes’ quadriceps using quantitative magnetic resonance imaging (qMRI) coupled with serological biomarkers. </span></p></div><div style=""><p style="padding: 0px; margin: 0px;"><span style="font-family: Arial, sans-serif; font-size: 14px;">The study aimed to monitor the longitudinal effect of the race and recovery, and to identify local inflammatory and metabolic muscle responses by codetection of biological markers. </span><span style="font-family: Arial, sans-serif; font-size: 14px; color: #353535;">An automatic image processing framework was designed to extract imaging-based biomarkers from qMRI acquisitions of the upper legs of 20 finishers at three time points. The longitudinal impact of the race was demonstrated by analyzing the image markers with dedicated biostatistical analysis. </span></p></div><div style=""><p style="padding: 0px; margin: 0px;"><span style="font-family: Arial, sans-serif; font-size: 14px; color: #353535;">Our framework allows a reliable calculation of statistical data not only inside the whole quadriceps volume but also within each individual muscle heads. Local changes in MRI parameters extracted from quantitative maps were described and found significantly correlated with principal serological biomarkers of interest. A decrease in the PDFF after the race and a stable paramagnetic susceptibility value were found. Pairwise post hoc tests suggested that the recovery process differs among the muscle heads.</span></p></div><div style=""><p style="padding: 0px; margin: 0px;"><span style="font-size: 14px;"><font face="Arial, sans-serif">This longitudinal study conducted during a prolonged and extreme mechanical stress, showed that quantitative MRI-based markers of inflammation and metabolic response can detect local changes related to the prolonged exercise, with differentiated involvement of each head of the quadriceps muscle as expected in such eccentric load. Consistent and efficient extraction of the local biomarkers enables to highlight interplay/interactions between blood and MRI biomarkers. This work indeed proposes an automatized analytic framework to tackle the time consuming and mentally exhausting segmentation task of muscle heads in large multi-time-points cohorts.</font></span></p></div>
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<img width="494" height="310" alt="" src="cid:image-13-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="display: block; width: 494px; height: 310px;" class="EQ-105"></div>
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<div style="text-align: justify; margin: 0px;"><font face="Arial, sans-serif"><i style="font-size: 14px;">Figures: 1) Flowchart
summarizing the main steps of our study. MRI was performed at three time
points: before (Pre), immediately after (Post) and ~48-72 h after the race (Post+3),
with biological sampling at four time points (an additional sample was
performed at half-race (Mid)). 2) C<span style="color: rgb(0, 0, 10);">oronal view of the automatic
segmentation displayed with the isotropic water image as a background and 3D volume rendering. 3) </span>Variation of
T2 along the race in the individual muscle heads of all finishers with an example of T2
maps at the three MR acquisition time points relative to the race in the same
subject. Abbreviations: VL – Vastus Lateralis, RF – Rectus Femoris, VM – Vastus
Medialis, VI – Vastus Intermedius.</i></font></div>
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<tr><td valign="top" class="EQ-06" align="center" width="494"><div class="layout-block-image"><img height="310" alt="" src="cid:image-13-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="display: block;" class="EQ-105" width="494"></img><div style="width:0px;height:0px;max-height:0;max-width:0;overflow:hidden;display:none;visibility:hidden;mso-hide:all;"></div></div></td><td class="layout-block-horizontal-spacer" width="10"> </td><td width="292" valign="top" align="left" class="EQ-06"><div class="text" style="font-size: 16px; font-family: sans-serif;">
<div style="text-align: justify;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif"><i style="font-size: 14px;">Figures: 1) Flowchart
summarizing the main steps of our study. MRI was performed at three time
points: before (Pre), immediately after (Post) and ~48-72 h after the race (Post+3),
with biological sampling at four time points (an additional sample was
performed at half-race (Mid)). 2) C<span style="color: #00000A;">oronal view of the automatic
segmentation displayed with the isotropic water image as a background and 3D volume rendering. 3) </span>Variation of
T2 along the race in the individual muscle heads of all finishers with an example of T2
maps at the three MR acquisition time points relative to the race in the same
subject. Abbreviations: VL – Vastus Lateralis, RF – Rectus Femoris, VM – Vastus
Medialis, VI – Vastus Intermedius.</i></font></p></div>
<div style="text-align: justify;"><span style="color: #00000A; font-size: 14px;"><font face="Arial, sans-serif"> </font></span></div>
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<td width="776" valign="top" align="left" background="cid:box-bg-33-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" style="padding-left: 10px; padding-right: 10px;" bgcolor="#ffffff">
<table cellspacing="0" cellpadding="0" class="EQ-07">
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';"><div style="margin-top: 0px; margin-bottom: 0px; text-align: justify; line-height: 1.2;"><font face="Arial, sans-serif" style="font-size: 15px;"><b><span style="text-decoration: underline; color: rgb(0, 0, 255);"><a href="https://doi.org/10.1002/nbm.4442"><b>Harmonic wideband simultaneous dual-frequency MR Elastography.</b></a></span></b> <b>Pilar Sango Solanas, Kevin Tse Ve Koon, Hélène Ratiney, Fabien Millioz, Cyrielle Caussy et Olivier Beuf. </b></font><span style="font-family: Arial, sans-serif; font-size: 15px;">NMR in Biomedicine, Nov 2020. </span></div><div style="margin-top: 0px; margin-bottom: 0px; line-height: inherit; text-align: justify;"><font face="Arial, sans-serif" style="font-size: 15px;"><br></font></div></div>
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<!--<![endif]--><!--[if gte mso 9]><div style="display:none;"><table cellspacing="0" cellpadding="0" class="EQ-00" width="816">
<tr><td width="10" class="layout-block-padding-left"> </td><td width="796" class="layout-block-content-cell" valign="top" align="left"><v:rect style="width:796px;" stroke="f"><v:fill type="tile" src="cid:box-bg-33-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" color="#ffffff"></v:fill><v:textbox style="mso-fit-shape-to-text:true" inset="0,0,0,0"><div><div style="font-size:0"><table cellspacing="0" cellpadding="0" class="EQ-07">
<tr><td style="font-size:1px;" width="10"> </td><td align="left" class="EQ-05" width="776"><div class="text" style="font-size: 16px; font-family: sans-serif;"><div style="text-align: justify; line-height: 120%;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 15px;"><b><span style="text-decoration: underline; color: #0000FF;"><a href="https://doi.org/10.1002/nbm.4442"><b>Harmonic wideband simultaneous dual-frequency MR Elastography.</b></a></span></b> <b>Pilar Sango Solanas, Kevin Tse Ve Koon, Hélène Ratiney, Fabien Millioz, Cyrielle Caussy et Olivier Beuf. </b></font><span style="font-family: Arial, sans-serif; font-size: 15px;">NMR in Biomedicine, Nov 2020. </span></p></div><div style="line-height: inherit; text-align: justify;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 15px;"><br></font></p></div></div></td><td style="font-size:1px;" width="10"> </td>
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<td width="796" class="EQ-18">
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<div class="text" style="text-align: justify; font-size: 16px; font-family: 'Lucida Grande';">
<div style="margin: 0px; line-height: inherit;"></div><div style="margin: 0px;"><font face="Arial, sans-serif" style="font-size: 14px;">Magnetic resonance elastography (MRE) is used to non-invasively quantify viscoelastic properties of tissues based on the measurement of propagation characteristics of shear waves. Because some of these viscoelastic parameters show a frequency dependence, multifrequency analysis allows us to measure the wave propagation dispersion, leading to a better characterization of tissue properties. Conventionally, motion encoding gradients (MEGs) oscillating at the same frequency as the mechanical excitation encode motion. Hence, multifrequency data is usually obtained by sequentially repeating monochromatic wave excitations experiments at different frequencies. The result is that the total acquisition time is multiplied by a factor corresponding to the number of repetitions of monofrequency experiments, which is a major limitation of multifrequency MRE. In order to make it more accessible, a novel single-shot harmonic wideband dual-frequency MRE method is proposed. Two superposed shear waves of different frequencies are simultaneously generated and propagate in a sample. Trapezoidal oscillating MEGs are used to encode mechanical vibrations having frequencies that are an odd multiple of the MEG frequency. The number of phase offsets is optimized to reduce the acquisition time. For this purpose, a sampling method not respecting the Shannon theorem is used to produce a controlled temporal aliasing that allows us to encode both frequencies without any additional examination time. Phantom experiments were run to compare conventional monofrequency MRE with the single-shot dual-frequency MRE method and showed excellent agreement between the reconstructed shear storage moduli G'. In addition, dual-frequency MRE yielded an increased signal-to-noise ratio compared with conventional monofrequency MRE acquisitions when encoding the high frequency component. The novel proposed multifrequency MRE method could be applied to simultaneously acquire more than two frequency components, reducing examination time. Further studies are needed to confirm its applicability in preclinical and clinical models.</font></div><div style="text-align: justify; margin: 0px 0px 8px; line-height: 1; color: rgb(0, 0, 0);"><br></div>
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<tr><td width="10" class="layout-block-padding-left"> </td><td width="796" class="layout-block-content-cell" valign="top" align="left"><v:rect style="width:796px;" stroke="f"><v:fill type="tile" src="cid:box-bg-33-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" color="#ffffff"></v:fill><v:textbox style="mso-fit-shape-to-text:true" inset="0,0,0,0"><div><div style="font-size:0"><table cellspacing="0" cellpadding="0" class="EQ-07">
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<div style="line-height: inherit;"><p style="padding: 0px; margin: 0px;"></p></div><div style=""><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 14px;">Magnetic resonance elastography (MRE) is used to non-invasively quantify viscoelastic properties of tissues based on the measurement of propagation characteristics of shear waves. Because some of these viscoelastic parameters show a frequency dependence, multifrequency analysis allows us to measure the wave propagation dispersion, leading to a better characterization of tissue properties. Conventionally, motion encoding gradients (MEGs) oscillating at the same frequency as the mechanical excitation encode motion. Hence, multifrequency data is usually obtained by sequentially repeating monochromatic wave excitations experiments at different frequencies. The result is that the total acquisition time is multiplied by a factor corresponding to the number of repetitions of monofrequency experiments, which is a major limitation of multifrequency MRE. In order to make it more accessible, a novel single-shot harmonic wideband dual-frequency MRE method is proposed. Two superposed shear waves of different frequencies are simultaneously generated and propagate in a sample. Trapezoidal oscillating MEGs are used to encode mechanical vibrations having frequencies that are an odd multiple of the MEG frequency. The number of phase offsets is optimized to reduce the acquisition time. For this purpose, a sampling method not respecting the Shannon theorem is used to produce a controlled temporal aliasing that allows us to encode both frequencies without any additional examination time. Phantom experiments were run to compare conventional monofrequency MRE with the single-shot dual-frequency MRE method and showed excellent agreement between the reconstructed shear storage moduli G'. In addition, dual-frequency MRE yielded an increased signal-to-noise ratio compared with conventional monofrequency MRE acquisitions when encoding the high frequency component. The novel proposed multifrequency MRE method could be applied to simultaneously acquire more than two frequency components, reducing examination time. Further studies are needed to confirm its applicability in preclinical and clinical models.</font></p></div><div style="text-align: justify; line-height: 100%; color: #000000;"><p style="padding: 0px; margin: 0px 0px 8px;"><br></p></div>
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';"><font style="font-size: 13px;"><i><b>Figures: (Left) </b></i></font><div style="font-family: 'Lucida Grande'; font-size: 16px;"></div><div style="text-align: justify; margin-top: 0px; margin-bottom: 0px; font-family: 'Lucida Grande'; font-size: 16px;"><font style="font-size: 13px;">Chronogram of the multifrequency acquisition pulse sequence.The period of the lowest-frequency mechanical vibration is denoted as T1. After the complete image of a phase offset has been acquired (green square), a delay ofT1/5 (red square) is added to perform the acquisition for the next phase offset image.</font></div><div style="margin-top: 0px; margin-bottom: 0px; font-family: 'Lucida Grande'; font-size: 16px;"><font style="font-size: 13px;"><br></font></div><div style="text-align: justify; margin-top: 0px; margin-bottom: 0px; font-family: 'Lucida Grande'; font-size: 16px;"><font style="font-size: 13px;"><i><b>(Right) </b></i>Phase image of the composite excitation (rad). Then separed in phase images (a.u.) of every frequency component extracted after temporal fourier transform: left, 300 Hz; right, 900 Hz. Finally, the G' elastograms (kPa) are reconstructed for each frequency component.</font></div></div>
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';"><font face="Arial, sans-serif" style="font-size: 13px;"><i><b>Figures: (Left) </b></i>
</font><div>
</div><div>
<div style="text-align: justify; margin: 0px;">
<font face="Arial, sans-serif" style="font-size: 13px;">Chronogram of the
multifrequency acquisition pulse sequence.The period of the lowest-frequency
mechanical vibration is denoted as T1. After
the complete image of a phase offset has
been acquired (green square), a delay ofT1/5
(red square) is added to perform the
acquisition for the next phase offset image.</font></div><div style="margin: 0px;"><font face="Arial, sans-serif" style="font-size: 13px;"><br></font></div><div style="text-align: justify; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 13px;"><i><b>(Right) </b></i><span style="text-align: justify;">Phase image of the composite excitation (rad). Then separed in phase images (a.u.) of every frequency component extracted after temporal fourier transform: left, 300 Hz; right, 900 Hz. Finally, the G' elastograms (kPa) are reconstructed for each frequency component.</span></font></div></div></div>
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</font><div>
</div><div>
<div style="text-align: justify;"><p style="padding: 0px; margin: 0px;">
<font face="Arial, sans-serif" style="font-size: 13px;">Chronogram of the
multifrequency acquisition pulse sequence.The period of the lowest-frequency
mechanical vibration is denoted as T1. After
the complete image of a phase offset has
been acquired (green square), a delay ofT1/5
(red square) is added to perform the
acquisition for the next phase offset image.</font></p></div><div style=""><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 13px;"><br></font></p></div><div style="text-align: justify;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 13px;"><i><b>(Right) </b></i><span style="text-align: justify;">Phase image of the composite excitation (rad). Then separed in phase images (a.u.) of every frequency component extracted after temporal fourier transform: left, 300 Hz; right, 900 Hz. Finally, the G' elastograms (kPa) are reconstructed for each frequency component.</span></font></p></div></div></div></td><td class="layout-block-3-columns spacer" width="10"> </td><td width="588" valign="top" class="layout-block-3-columns full-width" align="center" style="padding-right:10px;"><div class="layout-block-image"><img height="347" alt="" src="cid:image-9-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="padding-right: 0px; display: block;" class="" width="588"></img><div style="width:0px;height:0px;max-height:0;max-width:0;overflow:hidden;display:none;visibility:hidden;mso-hide:all;"></div></div></td>
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';"><div style="margin-top: 0px; margin-bottom: 0px; text-align: justify; line-height: 1.2;"><a href="https://pubmed.ncbi.nlm.nih.gov/33244043/" style="font-family: Helvetica; text-align: start; font-size: 15px;"><b>White matter microarchitecture and structural network integrity correlate with children intelligence quotient.</b></a></div><div style="margin-top: 0px; margin-bottom: 0px; text-align: justify; line-height: 1.2;"><span style="font-family: Helvetica; text-align: start; font-size: 15px;"></span></div><div style="font-family: Helvetica; text-align: start; margin-top: 0px; margin-bottom: 0px; line-height: 1.2;"><span style="font-size: 15px;"><b>Suprano I, Kocevar G, Stamile C, Hannoun S, Fourneret P, Revol O, Nusbaum F, Sappey-Marinier D.</b> Sci Rep. 2020 Nov 26;10(1):20722.<b> </b>doi: 10.1038/s41598-020-76528-x. PMID: 33244043 Free PMC article.</span></div><div style="margin-top: 0px; margin-bottom: 0px; line-height: inherit; text-align: justify;"><font face="Arial, sans-serif" style="font-size: 15px;"><br></font></div></div>
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<tr><td style="font-size:1px;" width="10"> </td><td align="left" class="EQ-05" width="776"><div class="text" style="font-size: 16px; font-family: sans-serif;"><div style="text-align: justify; line-height: 120%;"><p style="padding: 0px; margin: 0px;"><a href="https://pubmed.ncbi.nlm.nih.gov/33244043/" style="font-family: sans-serif; text-align: start; font-size: 15px;"><b>White matter microarchitecture and structural network integrity correlate with children intelligence quotient.</b></a></p></div><div style="text-align: justify; line-height: 120%;"><p style="padding: 0px; margin: 0px;"><span style="font-family: sans-serif; text-align: start; font-size: 15px;"></span></p></div><div style="font-family: sans-serif; text-align: start; line-height: 120%;"><p style="padding: 0px; margin: 0px;"><span style="font-size: 15px;"><b>Suprano I, Kocevar G, Stamile C, Hannoun S, Fourneret P, Revol O, Nusbaum F, Sappey-Marinier D.</b> Sci Rep. 2020 Nov 26;10(1):20722.<b> </b>doi: 10.1038/s41598-020-76528-x. PMID: 33244043 Free PMC article.</span></p></div><div style="line-height: inherit; text-align: justify;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 15px;"><br></font></p></div></div></td><td style="font-size:1px;" width="10"> </td>
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<td width="776" valign="top" align="left" background="cid:box-bg-33-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" style="padding-left: 10px; padding-right: 10px;" bgcolor="#ffffff">
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<div style="margin: 0px; line-height: inherit;"></div><div style="text-align: start; margin: 0px;"><span style="color: rgb(33, 33, 33); font-size: 14px;"><font face="Arial, sans-serif">The neural substrate of high intelligence performances remains not well understood. Based on diffusion tensor imaging (DTI) which provides microstructural information of white matter fibers, we proposed in this work to investigate the relationship between structural brain connectivity and intelligence quotient (IQ) scores. Fifty-seven children (8-12 y.o.) underwent a MRI examination, including conventional T1-weighted and DTI sequences, and neuropsychological testing using the fourth edition of Wechsler Intelligence Scale for Children (WISC-IV), providing an estimation of the Full-Scale Intelligence Quotient (FSIQ) based on four subscales: verbal comprehension index (VCI), perceptual reasoning index (PRI), working memory index (WMI), and processing speed index (PSI). Correlations between the IQ scores and both graphs and diffusivity metrics were explored. First, we found significant correlations between the increased integrity of WM fiber-bundles and high intelligence scores. Second, the graph theory analysis showed that integration and segregation graph metrics were positively and negatively correlated with WISC-IV scores, respectively. These results were mainly driven by significant correlations between FSIQ, VCI, and PRI and graph metrics in the temporal and parietal lobes. In conclusion, these findings demonstrated that intelligence performances are related to the integrity of WM fiber-bundles as well as the density and homogeneity of WM brain networks.</font></span></div><div style="margin: 0px;"><br></div>
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<tr><td style="font-size:1px;" width="10"> </td><td align="left" class="EQ-05" width="776"><div class="text" style="text-align: justify; font-size: 16px; font-family: sans-serif;">
<div style="line-height: inherit;"><p style="padding: 0px; margin: 0px;"></p></div><div style="text-align: start;"><p style="padding: 0px; margin: 0px;"><span style="color: #212121; font-size: 14px;"><font face="Arial, sans-serif">The neural substrate of high intelligence performances remains not well understood. Based on diffusion tensor imaging (DTI) which provides microstructural information of white matter fibers, we proposed in this work to investigate the relationship between structural brain connectivity and intelligence quotient (IQ) scores. Fifty-seven children (8-12 y.o.) underwent a MRI examination, including conventional T1-weighted and DTI sequences, and neuropsychological testing using the fourth edition of Wechsler Intelligence Scale for Children (WISC-IV), providing an estimation of the Full-Scale Intelligence Quotient (FSIQ) based on four subscales: verbal comprehension index (VCI), perceptual reasoning index (PRI), working memory index (WMI), and processing speed index (PSI). Correlations between the IQ scores and both graphs and diffusivity metrics were explored. First, we found significant correlations between the increased integrity of WM fiber-bundles and high intelligence scores. Second, the graph theory analysis showed that integration and segregation graph metrics were positively and negatively correlated with WISC-IV scores, respectively. These results were mainly driven by significant correlations between FSIQ, VCI, and PRI and graph metrics in the temporal and parietal lobes. In conclusion, these findings demonstrated that intelligence performances are related to the integrity of WM fiber-bundles as well as the density and homogeneity of WM brain networks.</font></span></p></div><div style=""><p style="padding: 0px; margin: 0px;"><br></p></div>
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<span style="font-size: 14px;"><font face="Arial, sans-serif">Figure: Significant correlations obtained between the full-scale intelligence quotient (FSIQ) and the local
graph metrics in the left precuneus and the left middle temporal networks. Image drawn with Connectome
Workbench toolbox v1.3.2 (<span style="color: rgb(0, 0, 255);">https://humanconnectome.org/software/connectome-workbench</span>). </font></span>
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<span style="font-size: 14px;"><font face="Arial, sans-serif">Figure: Significant correlations obtained between the full-scale intelligence quotient (FSIQ) and the local
graph metrics in the left precuneus and the left middle temporal networks. Image drawn with Connectome
Workbench toolbox v1.3.2 (<span style="color: #0000FF;">https://humanconnectome.org/software/connectome-workbench</span>). </font></span>
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande'; text-align: justify;"><font face="Arial, sans-serif" style="font-weight: bold; font-family: Arial, sans-serif;">FLASH THESE: </font><b><font face="Arial, sans-serif" style="font-family: Arial, sans-serif;">"</font></b><b style="font-family: Arial, sans-serif; font-size: 14px;">Salim </b><font face="Arial, sans-serif"><span style="font-size: 14px;"><b>Aymeric SI-MOHAMED</b></span></font></div>
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<tr><td style="font-size:1px;"> </td><td width="760" valign="top" align="left"><div class="heading" style="font-size: 16px; font-family: sans-serif; text-align: justify;"><font face="Arial, sans-serif" style="font-weight: bold; font-family: Arial, sans-serif;">FLASH THESE: </font><b><font face="Arial, sans-serif" style="font-family: Arial, sans-serif;">"</font></b><b style="font-family: Arial, sans-serif; font-size: 14px;">Salim </b><font face="Arial, sans-serif"><span style="font-size: 14px;"><b>Aymeric SI-MOHAMED</b></span></font></div></td><td style="font-size:1px;"> </td>
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';"><div><span style="font-size: 14px;"><font face="Arial, sans-serif"><b>Apport de l'imagerie spectrale tomodensitométrique à comptage photonique pour l'imagerie cardiovasculaire (Spectral photon-counting computed tomography in cardiovascular imaging)</b></font></span></div><div><span style="font-size: 14px;"><font face="Arial, sans-serif"><br></font></span></div><div style="text-align: justify; "><span style="font-size: 14px;"><font face="Arial, sans-serif">L'avènement de nouveaux détecteurs, dits à comptage photonique, appliqués à la tomodensitométrie aux rayons X permet l'analyse de la composition énergétique du spectre de rayons X transmis. En divisant le spectre en plusieurs fenêtres énergétiques, l’imagerie « multicouleur » spécifique et quantitative de matériaux (tels que le gadolinium et l'or), également appelée imagerie K-edge, est possible. Parallèlement, les nanoparticules d'or (AuNP) s'avèrent de bonnes candidates pour l'imagerie K-edge en raison de leur énergie Kedge élevée (~80.3 keV). De plus, elles ont le potentiel de circuler plus longtemps que les agents de contraste iodés pour une meilleure imagerie du compartiment vasculaire et d'être biocompatibles pour des applications in vivo. L'objectif principal de ce travail de thèse est d'évaluer l'imagerie K-edge in vitro et in vivo, permise par un prototype préclinique de tomodensitométrie spectrale à comptage photonique, en combinaison avec des AuNP pégylées et des produits de contraste approuvés cliniquement à base d'iode et de gadolinium pour l'imagerie de la lumière et de la paroi artérielle chez le lapin sain et athéromateux. Notre principale contribution a été de démontrer que l'imagerie K-edge est réalisable in vivo en combinaison avec des nanoparticules d'or pour améliorer l'évaluation spécifique de la paroi artérielle athéromateuse en comparaison à l'imagerie conventionnelle via la quantification de sa charge macrophagique, ainsi que pour réaliser une imagerie spécifique « bicouleur » de la lumière artérielle marquée par un produit de contraste iodé et la plaque marquée par les AuNP.</font></span></div><div><span style="font-size: 14px;"><font face="Arial, sans-serif"><br></font></span></div><div><span style="font-size: 14px;"><font face="Arial, sans-serif">La thèse peut être ré-écoutée sur YouTube ici: <a href="https://youtu.be/JvLg_ecq2Go">https://youtu.be/JvLg_ecq2Go</a></font></span></div></div>
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<tr><td width="10" class="layout-block-padding-left"> </td><td width="796" class="layout-block-content-cell" valign="top" align="left"><v:rect style="width:796px;" stroke="f"><v:fill type="tile" src="cid:box-bg-22-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" color="#ffffff"></v:fill><v:textbox style="mso-fit-shape-to-text:true" inset="0,0,0,0"><div><div style="font-size:0"><table cellspacing="0" cellpadding="0" class="EQ-07">
<tr><td style="font-size:1px;" width="10"> </td><td align="left" class="EQ-05" width="776"><div class="text" style="font-size: 16px; font-family: sans-serif;"><div><span style="font-size: 14px;"><font face="Arial, sans-serif"><b>Apport de l'imagerie spectrale tomodensitométrique à comptage photonique pour l'imagerie cardiovasculaire (Spectral photon-counting computed tomography in cardiovascular imaging)</b></font></span></div><div><span style="font-size: 14px;"><font face="Arial, sans-serif"><br></font></span></div><div style="text-align: justify;"><span style="font-size: 14px;"><font face="Arial, sans-serif">L'avènement de nouveaux détecteurs, dits à comptage photonique, appliqués à la tomodensitométrie aux rayons X permet l'analyse de la composition énergétique du spectre de rayons X transmis. En divisant le spectre en plusieurs fenêtres énergétiques, l’imagerie « multicouleur » spécifique et quantitative de matériaux (tels que le gadolinium et l'or), également appelée imagerie K-edge, est possible. Parallèlement, les nanoparticules d'or (AuNP) s'avèrent de bonnes candidates pour l'imagerie K-edge en raison de leur énergie Kedge élevée (~80.3 keV). De plus, elles ont le potentiel de circuler plus longtemps que les agents de contraste iodés pour une meilleure imagerie du compartiment vasculaire et d'être biocompatibles pour des applications in vivo. L'objectif principal de ce travail de thèse est d'évaluer l'imagerie K-edge in vitro et in vivo, permise par un prototype préclinique de tomodensitométrie spectrale à comptage photonique, en combinaison avec des AuNP pégylées et des produits de contraste approuvés cliniquement à base d'iode et de gadolinium pour l'imagerie de la lumière et de la paroi artérielle chez le lapin sain et athéromateux. Notre principale contribution a été de démontrer que l'imagerie K-edge est réalisable in vivo en combinaison avec des nanoparticules d'or pour améliorer l'évaluation spécifique de la paroi artérielle athéromateuse en comparaison à l'imagerie conventionnelle via la quantification de sa charge macrophagique, ainsi que pour réaliser une imagerie spécifique « bicouleur » de la lumière artérielle marquée par un produit de contraste iodé et la plaque marquée par les AuNP.</font></span></div><div><span style="font-size: 14px;"><font face="Arial, sans-serif"><br></font></span></div><div><span style="font-size: 14px;"><font face="Arial, sans-serif">La thèse peut être ré-écoutée sur YouTube ici: <a href="https://youtu.be/JvLg_ecq2Go">https://youtu.be/JvLg_ecq2Go</a></font></span></div></div></td><td style="font-size:1px;" width="10"> </td>
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';"><font face="Arial, sans-serif" style="font-weight: bold; font-family: Arial, sans-serif; color: rgb(0, 0, 0);">FLASH CARRIERE: </font><b><font face="Arial, sans-serif" style="font-size: 16px; font-family: Arial, sans-serif; color: rgb(0, 0, 0);">"</font></b><b style="font-family: Arial, sans-serif; font-size: 14px; text-align: justify;">Leonardo Flórez Valencia</b><b><font face="Arial, sans-serif">"</font></b><br></div>
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';"><div style="text-align: justify; line-height: 1.3; letter-spacing: 0.008em; margin-bottom: 1em;">
</div><div style="text-align: justify; margin: 0px; line-height: 107%;"><span style="font-size: 14px;"><font face="Arial, sans-serif"><span style="line-height: 107%;"><b>Leonardo Flórez Valencia </b>est<b> </b>né en
1978 à Bogotá, Colombie. Il a fait ses études d’ingénieur en informatique (2000)
puis master en informatique (2002) à la Universidad de los Andes de Bogotá. En
parallèle, il a effectué un stage de six mois à CREATIS (février-août 2001),
puis un Diplôme d’Etudes Approfondies à l’INSA de Lyon avec un stage de
recherche à CREATIS (2002). C’est également à CREATIS qu’il a préparé sa <b>thèse
de doctorat (2006)</b>, dans le cadre d’un contrat CIFRE avec la société Theralys.
Depuis janvier 2007, il est enseignant-chercheur au Département d’Informatique
de la Pontificia Universidad Javeriana à Bogotá. Il a gardé des liens étroits
avec CREATIS où il revient régulièrement pour des séjours d’une à deux
semaines. En 2014, il a effectué un séjour de quatre mois comme chercheur
invité. Six de ses étudiants colombiens ont effectué des stages au sein
d’info-dev et deux d’entre eux ont également réalisé à CREATIS leur projet de
recherche master. Il a co-signé, avec des chercheurs de CREATIS, huit articles
dans des revues spécialisées, un chapitre d’ouvrage collectif et vingt
communications à des conférences. L’année 2020 marque deux importants dans sa
carrière professionnelle : le démarrage d’un master en intelligence
artificielle qu’il a monté au sein de son université et dont il est le
responsable, et sa promotion au grade de professeur. Félicitations !</span></font></span></div><div style="text-align: justify; margin: 0px; line-height: 107%;"><span style="font-size: 14px;"><font face="Arial, sans-serif"><span style="line-height: 107%;"><br></span></font></span></div>
<div style="text-align: justify; margin: 0px; line-height: 115%;"><font face="Arial, sans-serif" style="font-size: 13px;"><i><span style="letter-spacing: 0.10199999809265137px;">Figure: (Haut) Photo portrait de Leonardo. (Bas) </span><span style="line-height: 107%;">Utilisation
d’un modèle de cylindre généralisé pour simuler le déploiement d’un stent dans
un vaisseau intracrânien. Travail réalisé par Leonardo dans le cadre du projet
européen </span><a href="http://www.thrombus-vph.eu/"><span style="line-height: 107%;">Thrombus</span></a><span style="line-height: 107%;"> en partant
de ses travaux de thèse.</span></i></font></div>
<div style="margin: 0px; line-height: 107%;"><i><font face="Arial, sans-serif" style="font-size: 13px;"> </font></i><br></div>
</div>
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<table width="187" cellspacing="0" cellpadding="0" align="left" class="EQ-04">
<tbody><tr>
<td align="left" valign="top" class="EQ-05" width="187">
<div class="layout-block-image">
<img width="187" height="334" alt="" src="cid:image-21-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="display: block; width: 187px; height: 334px;" class="EQ-178"></div>
</td>
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</td>
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</tbody></table>
</td>
</tr>
</tbody></table>
<!--<![endif]--><!--[if gte mso 9]><div style="display:none;"><table style="font-size:0"><tbody><tr><td><v:rect style="width:816px;" stroke="f"><v:fill type="tile" src="cid:box-bg-73-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" color="#ffffff"></v:fill><v:textbox style="mso-fit-shape-to-text:true" inset="0,0,0,0"><div><div style="font-size:0"><table cellspacing="0" cellpadding="0" class="EQ-00" width="816">
<tr><td width="816" valign="top" align="left" class="layout-block-content-cell"><table cellspacing="0" cellpadding="0" class="mso-fixed-width layout-block-content-cell">
<tr><td align="left" valign="top" class="layout-block-content-cell" style="padding-left:30px; padding-right:30px;"><div class="text" style="font-size: 16px; font-family: sans-serif;"><div style="text-align: justify; line-height: 130%; letter-spacing: 0.008em;"><p style="padding: 0px; margin: 0px 0px 1em;">
</p></div><div style="text-align: justify; line-height: 107%;"><p style="padding: 0px; margin: 0px;"><span style="font-size: 14px;"><font face="Arial, sans-serif"><span style="line-height: 107%;"><b>Leonardo Flórez Valencia </b>est<b> </b>né en
1978 à Bogotá, Colombie. Il a fait ses études d’ingénieur en informatique (2000)
puis master en informatique (2002) à la Universidad de los Andes de Bogotá. En
parallèle, il a effectué un stage de six mois à CREATIS (février-août 2001),
puis un Diplôme d’Etudes Approfondies à l’INSA de Lyon avec un stage de
recherche à CREATIS (2002). C’est également à CREATIS qu’il a préparé sa <b>thèse
de doctorat (2006)</b>, dans le cadre d’un contrat CIFRE avec la société Theralys.
Depuis janvier 2007, il est enseignant-chercheur au Département d’Informatique
de la Pontificia Universidad Javeriana à Bogotá. Il a gardé des liens étroits
avec CREATIS où il revient régulièrement pour des séjours d’une à deux
semaines. En 2014, il a effectué un séjour de quatre mois comme chercheur
invité. Six de ses étudiants colombiens ont effectué des stages au sein
d’info-dev et deux d’entre eux ont également réalisé à CREATIS leur projet de
recherche master. Il a co-signé, avec des chercheurs de CREATIS, huit articles
dans des revues spécialisées, un chapitre d’ouvrage collectif et vingt
communications à des conférences. L’année 2020 marque deux importants dans sa
carrière professionnelle : le démarrage d’un master en intelligence
artificielle qu’il a monté au sein de son université et dont il est le
responsable, et sa promotion au grade de professeur. Félicitations !</span></font></span></p></div><div style="text-align: justify; line-height: 107%;"><p style="padding: 0px; margin: 0px;"><span style="font-size: 14px;"><font face="Arial, sans-serif"><span style="line-height: 107%;"><br></span></font></span></p></div>
<div style="text-align: justify; line-height: 115%;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 13px;"><i><span style="letter-spacing: 0.10199999809265137px;">Figure: (Haut) Photo portrait de Leonardo. (Bas) </span><span style="line-height: 107%;">Utilisation
d’un modèle de cylindre généralisé pour simuler le déploiement d’un stent dans
un vaisseau intracrânien. Travail réalisé par Leonardo dans le cadre du projet
européen </span><a href="http://www.thrombus-vph.eu/"><span style="line-height: 107%;">Thrombus</span></a><span style="line-height: 107%;"> en partant
de ses travaux de thèse.</span></i></font></p></div>
<div style="line-height: 107%;"><p style="padding: 0px; margin: 0px;"><i><font face="Arial, sans-serif" style="font-size: 13px;"> </font></i><br></p></div>
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande'; text-align: justify; line-height: 1.5;">
<font style="line-height: 1.5;" face="Arial, sans-serif"><b>ARRIVEES</b></font></div>
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<font style="line-height: 150%;" face="Arial, sans-serif"><b>ARRIVEES</b></font></div></td><td style="font-size:1px;" width="10"> </td>
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<table cellspacing="0" cellpadding="0" align="left" class="EQ-06" width="127">
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<img width="127" height="152" alt="" src="cid:image-8-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="line-height: 1px; display: block; width: 127px; height: 152px;" class="EQ-189"></div>
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<table cellspacing="0" cellpadding="0" align="left" class="EQ-06" width="659">
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<td width="659" valign="top" align="left" class="EQ-06">
<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';">
<div style="text-align: justify; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 13px;"><b>Ane Etxebeste </b></font><span style="text-align: start;"><font face="Arial, sans-serif" style="font-size: 13px;">a
été recrutée en tant que Maître de Conférences section 27 à Creatis en
recherche et au département FIMI de l’INSA. Licenciée en physique générale de
l’Université du Pays Basque (Espagne), Ane a réalisé un doctorat en imagerie
médicale portant sur la tomographie par émission de positons à l’Université de
Valencia entre 2013 et 2017. Ane a ensuite réalisé deux ans de post-doctorat à Creatis et 8 mois de post-doctorat à
l’Institut de Physique des 2 Infinis (IP2I) de Lyon sur l’imagerie Compton en
physique médicale. Elle a été impliquée dans le développement des simulations
Monte Carlo. Elle vient de rejoindre l’équipe 4 (tomoradio) en septembre.</font></span></div><div style="margin: 0px; text-align: start;">
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<td width="10" class="EQ-16"> </td>
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<tr><td valign="top" class="EQ-06" align="center" width="127"><div class="layout-block-image"><img height="152" alt="" src="cid:image-8-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="line-height: 1px; display: block;" class="EQ-189" width="127"></img><div style="width:0px;height:0px;max-height:0;max-width:0;overflow:hidden;display:none;visibility:hidden;mso-hide:all;"></div></div></td><td class="layout-block-horizontal-spacer" width="10"> </td><td width="659" valign="top" align="left" class="EQ-06"><div class="text" style="font-size: 16px; font-family: sans-serif;">
<div style="text-align: justify;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 13px;"><b>Ane Etxebeste </b></font><span style="text-align: start;"><font face="Arial, sans-serif" style="font-size: 13px;">a
été recrutée en tant que Maître de Conférences section 27 à Creatis en
recherche et au département FIMI de l’INSA. Licenciée en physique générale de
l’Université du Pays Basque (Espagne), Ane a réalisé un doctorat en imagerie
médicale portant sur la tomographie par émission de positons à l’Université de
Valencia entre 2013 et 2017. Ane a ensuite réalisé deux ans de post-doctorat à Creatis et 8 mois de post-doctorat à
l’Institut de Physique des 2 Infinis (IP2I) de Lyon sur l’imagerie Compton en
physique médicale. Elle a été impliquée dans le développement des simulations
Monte Carlo. Elle vient de rejoindre l’équipe 4 (tomoradio) en septembre.</font></span></p></div><div style="text-align: start;"><p style="padding: 0px; margin: 0px;">
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<table cellspacing="0" cellpadding="0" align="left" class="EQ-06" width="127">
<tbody><tr>
<td width="127" valign="top" class="EQ-06" align="center">
<div class="layout-block-image">
<img width="127" height="138" alt="" src="cid:image-18-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="line-height: 1px; display: block; width: 127px; height: 138px;" class="EQ-193"></div>
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<table cellspacing="0" cellpadding="0" align="left" class="layout-block-horizontal-spacer" width="10">
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<tbody><tr>
<td width="659" valign="top" align="left" class="EQ-06">
<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';">
<div style="text-align: justify; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 13px;"><b>Pauline Queiros: "</b>Lauréate du concours
externe d’adjoint administratif principal de 2ème classe en août
2020, j’intègre l’université Lyon 1 et plus particulièrement l’équipe administrative
de <b>CREATIS</b> en tant que référente RH le 03 septembre 2020. Titulaire d’un Master
1 Métiers de l’Enseignement, de l’éducation et de la formation 1er
degré ainsi que d’une Licence Sciences du langage, c’est avec joie que je
débute ma carrière professionnelle dans l’Enseignement Supérieur et la
Recherche. N’ayant jamais eu l’occasion de travailler dans l’administration et
pour la recherche jusqu’à présent, c’est avec entrain et dynamisme que je
prends plaisir à travailler auprès des équipes de <b>CREATIS</b>.
</font></div><div style="margin: 0px; text-align: start;"><font face="Arial, sans-serif" style="font-size: 13px;"><br></font></div>
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<td width="10" class="EQ-16"> </td>
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<tr><td valign="top" class="EQ-06" align="center" width="127"><div class="layout-block-image"><img height="138" alt="" src="cid:image-18-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="line-height: 1px; display: block;" class="EQ-193" width="127"></img><div style="width:0px;height:0px;max-height:0;max-width:0;overflow:hidden;display:none;visibility:hidden;mso-hide:all;"></div></div></td><td class="layout-block-horizontal-spacer" width="10"> </td><td width="659" valign="top" align="left" class="EQ-06"><div class="text" style="font-size: 16px; font-family: sans-serif;">
<div style="text-align: justify;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 13px;"><b>Pauline Queiros: "</b>Lauréate du concours
externe d’adjoint administratif principal de 2ème classe en août
2020, j’intègre l’université Lyon 1 et plus particulièrement l’équipe administrative
de <b>CREATIS</b> en tant que référente RH le 03 septembre 2020. Titulaire d’un Master
1 Métiers de l’Enseignement, de l’éducation et de la formation 1er
degré ainsi que d’une Licence Sciences du langage, c’est avec joie que je
débute ma carrière professionnelle dans l’Enseignement Supérieur et la
Recherche. N’ayant jamais eu l’occasion de travailler dans l’administration et
pour la recherche jusqu’à présent, c’est avec entrain et dynamisme que je
prends plaisir à travailler auprès des équipes de <b>CREATIS</b>.
</font></p></div><div style="text-align: start;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 13px;"><br></font></p></div>
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<tbody><tr>
<td width="127" valign="top" class="EQ-06" align="center">
<div class="layout-block-image">
<img width="127" height="157" alt="" src="cid:image-6-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="line-height: 1px; display: block; width: 127px; height: 157px;" class="EQ-197"></div>
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande'; text-align: justify; margin: 0px;">
<font style="font-size: 13px;"><font face="Arial, sans-serif"><b>Antoine Naegel </b></font><span style="font-family: Helvetica; text-align: start;">est diplômé de l'école d'ingénieur Polytech Lyon en spécialité génie biomédical. Il a effectué, entre mars et août 2020, son stage de fin d’étude au laboratoire au sein de l'équipe 5. Son projet de thèse s'inscrit dans la continuité de ce stage. Cette thèse CIFRE e</span></font><span style="font-family: Helvetica; font-size: 13px;">n partenariat avec Siemens Healthineers, </span><font face="Helvetica" style="font-size: 13px;">a pour objectif l’ "Optimisation des approches multi-noyaux (1H, 31P, 13C) combinées à des techniques d’IRM avancées pour l’exploration non-invasive du muscle in-vivo" et s’effectuera </font><font face="Helvetica" style="font-size: 13px;">sous l'encadrement de Magalie Viallon et de Hélène Ratiney. Cette thèse consistera à élaborer des développements méthodologiques en spectroscopie RMN spécifiques à ces noyaux exotiques, sur un imageur clinique 3T dans le but d'une exploration métabolique et fonctionnelle plus complète du muscle in-vivo. Ces développements compléteront le port-folio d’exploration du métabolisme musculaire lors de l’effort, de la récupération et seront déployée sur les études cliniques en cours dédiées à l’étude de la fatigue après séjour en réanimation ou en monitoring lors de la rééducation.</font>
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<font style="font-size: 13px;"><font face="Arial, sans-serif"><b>Antoine Naegel </b></font><span style="font-family: sans-serif; text-align: start;">est diplômé de l'école d'ingénieur Polytech Lyon en spécialité génie biomédical. Il a effectué, entre mars et août 2020, son stage de fin d’étude au laboratoire au sein de l'équipe 5. Son projet de thèse s'inscrit dans la continuité de ce stage. Cette thèse CIFRE e</span></font><span style="font-family: sans-serif; font-size: 13px;">n partenariat avec Siemens Healthineers, </span><font face="sans-serif" style="font-size: 13px;">a pour objectif l’ "Optimisation des approches multi-noyaux (1H, 31P, 13C) combinées à des techniques d’IRM avancées pour l’exploration non-invasive du muscle in-vivo" et s’effectuera </font><font face="sans-serif" style="font-size: 13px;">sous l'encadrement de Magalie Viallon et de Hélène Ratiney. Cette thèse consistera à élaborer des développements méthodologiques en spectroscopie RMN spécifiques à ces noyaux exotiques, sur un imageur clinique 3T dans le but d'une exploration métabolique et fonctionnelle plus complète du muscle in-vivo. Ces développements compléteront le port-folio d’exploration du métabolisme musculaire lors de l’effort, de la récupération et seront déployée sur les études cliniques en cours dédiées à l’étude de la fatigue après séjour en réanimation ou en monitoring lors de la rééducation.</font>
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<div style="text-align: justify;"><font face="Arial, sans-serif" style="font-size: 13px;"><b>Cyril Malinet </b>est<b> </b>SupOpticien de formation: " j'ai commencé ma thèse financée par le Labex PRIMES en septembre dernier sous la responsabilité d'une équipe d'encadrement issue des équipes ULTIM et MAGICS. Hervé Liebgott et Pauline Muleki-Seya sont experts des ultrasons et Bruno Montcel est expert en imagerie optique. Nous travaillons également en collaboration avec Aurélie Dutour, biologiste moléculaire du centre Léon Bérard. <span style="text-align: start;">Mon projet de thèse s'intitule : Evaluation de la microstructure tissulaire par spectroscopie ultrasonore et optique pour la caractérisation du cancer.</span></font><span style="font-size: 13px; font-family: Arial, sans-serif;"> L'objectif de ma thèse est de confronter les résultats issues de l'approche ultrasonore et optique afin de valider la complémentarité de cette méthode bimodale pour la caractérisation du cancer. Après avoir validé les mesures sur des fantômes, nous planifions de réaliser des acquisitions sur des modèles in vitro de chondromes fournis par Aurélie Dutour du centre Léon Bérard. Des mesures in vivo sont également envisagées."</span></div><div style="text-align: justify;"><font face="Arial, sans-serif" style="font-size: 13px;"><br></font></div>
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<div style="text-align: justify;"><font face="Arial, sans-serif" style="font-size: 13px;"><b>Cyril Malinet </b>est<b> </b>SupOpticien de formation: " j'ai commencé ma thèse financée par le Labex PRIMES en septembre dernier sous la responsabilité d'une équipe d'encadrement issue des équipes ULTIM et MAGICS. Hervé Liebgott et Pauline Muleki-Seya sont experts des ultrasons et Bruno Montcel est expert en imagerie optique. Nous travaillons également en collaboration avec Aurélie Dutour, biologiste moléculaire du centre Léon Bérard. <span style="text-align: start;">Mon projet de thèse s'intitule : Evaluation de la microstructure tissulaire par spectroscopie ultrasonore et optique pour la caractérisation du cancer.</span></font><span style="font-size: 13px; font-family: Arial, sans-serif;"> L'objectif de ma thèse est de confronter les résultats issues de l'approche ultrasonore et optique afin de valider la complémentarité de cette méthode bimodale pour la caractérisation du cancer. Après avoir validé les mesures sur des fantômes, nous planifions de réaliser des acquisitions sur des modèles in vitro de chondromes fournis par Aurélie Dutour du centre Léon Bérard. Des mesures in vivo sont également envisagées."</span></div><div style="text-align: justify;"><font face="Arial, sans-serif" style="font-size: 13px;"><br></font></div>
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<div style="text-align: justify; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 13px;"><b>Nicolas Pinon</b> est diplômé de l'Ecole Normale Supérieure (ENS) Paris-Saclay en génie électrique et de l'ENS Paris-Saclay en mathématiques, vision par ordinateur et apprentissage statistique (MVA). Il a précédemment travaillé sur la détection de la symétrie en IRM de la moelle épinière et a rejoint l'équipe MYRIAD de CREATIS en avril dernier, travaillant sur la segmentation des masques de mouvement dans les scanners pulmonaires. Il a commencé début décembre en tant que doctorant sur un projet intitulé "Contributions méthodologiques dans l'apprentissage statistique non supervisé et faiblement supervisé pour la détection d'anomalies en neuroimagerie" sous la supervision de <b>Carole Lartizien.</b> Les deux applications cliniques ciblées concernent la détection des lésions épileptiques et l'évaluation de la charge des lésions microhémorragiques chez les patients COVID19, en collaboration avec des cliniciens de HCL. Ce projet de doctorat est accordé par l'ENS et contribuera au projet TADALOT financé par la Région Rhône Auvergne Rhône Alpes.</font></div><div style="margin: 0px; text-align: justify;"><font face="Arial, sans-serif" style="font-size: 13px;"><br></font></div>
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<div style="text-align: justify;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 13px;"><b>Nicolas Pinon</b> est diplômé de l'Ecole Normale Supérieure (ENS) Paris-Saclay en génie électrique et de l'ENS Paris-Saclay en mathématiques, vision par ordinateur et apprentissage statistique (MVA). Il a précédemment travaillé sur la détection de la symétrie en IRM de la moelle épinière et a rejoint l'équipe MYRIAD de CREATIS en avril dernier, travaillant sur la segmentation des masques de mouvement dans les scanners pulmonaires. Il a commencé début décembre en tant que doctorant sur un projet intitulé "Contributions méthodologiques dans l'apprentissage statistique non supervisé et faiblement supervisé pour la détection d'anomalies en neuroimagerie" sous la supervision de <b>Carole Lartizien.</b> Les deux applications cliniques ciblées concernent la détection des lésions épileptiques et l'évaluation de la charge des lésions microhémorragiques chez les patients COVID19, en collaboration avec des cliniciens de HCL. Ce projet de doctorat est accordé par l'ENS et contribuera au projet TADALOT financé par la Région Rhône Auvergne Rhône Alpes.</font></p></div><div style="text-align: justify;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 13px;"><br></font></p></div>
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<div style="text-align: justify; margin: 0px;"><font style="font-size: 13px;"><font face="Arial, sans-serif"><b>Antoine Fraissenon </b>démarre une thèse de science intitulée<b> "</b>Phénotypage et suivi radiologique des patients atteints de PIK3CA" sous la supervision de </font><span style="font-family: Arial, sans-serif;"><b>P. Clarysse</b> (CREATIS, Lyon), <b>G. CANAUD</b> (Hôpital Necker, Paris), <b>E. Roux</b> (CREATIS, Lyon), en collaboration avec <b><font style="font-size: 13px;"><a href="http://kitware.fr"><b>Kitware</b></a></font></b> (<b>Lyon</b>). L'objectif de son doctorat est de développer des algorithmes de segmentation IRM robustes pour le suivi de pathologies rares telles que les malformations vasculaires et les lésions induites par la mutation PIK3CA. Il combinera l'apprentissage contradictoire et les techniques d'adaptation au domaine pour faire face à la grande variabilité des lésions, tant en termes de localisation que de forme.</span></font></div><div style="margin-top: 0px; margin-bottom: 0px; text-align: justify;"><br></div>
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<div style="text-align: justify;"><p style="padding: 0px; margin: 0px;"><font style="font-size: 13px;"><font face="Arial, sans-serif"><b>Antoine Fraissenon </b>démarre une thèse de science intitulée<b> "</b>Phénotypage et suivi radiologique des patients atteints de PIK3CA" sous la supervision de </font><span style="font-family: Arial, sans-serif;"><b>P. Clarysse</b> (CREATIS, Lyon), <b>G. CANAUD</b> (Hôpital Necker, Paris), <b>E. Roux</b> (CREATIS, Lyon), en collaboration avec <b><font style="font-size: 13px;"><a href="http://kitware.fr"><b>Kitware</b></a></font></b> (<b>Lyon</b>). L'objectif de son doctorat est de développer des algorithmes de segmentation IRM robustes pour le suivi de pathologies rares telles que les malformations vasculaires et les lésions induites par la mutation PIK3CA. Il combinera l'apprentissage contradictoire et les techniques d'adaptation au domaine pour faire face à la grande variabilité des lésions, tant en termes de localisation que de forme.</span></font></p></div><div style="text-align: justify;"><p style="padding: 0px; margin: 0px;"><br></p></div>
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<div style="text-align: justify; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 13px;"><b>Yamil Vindas </b></font><span style="font-family: Arial, sans-serif; font-size: 13px;">démarre sa thèse de science intitulée "Apprentissage faiblement supervisé pour la caractérisation des emboles avec le suivi Doppler Transcranien (TCD)" sous la supervision de </span><b style="font-size: 13px; font-family: Arial, sans-serif;">P. Delachartre</b><span style="font-size: 13px; font-family: Arial, sans-serif;"> (CREATIS, Lyon), </span><b style="font-size: 13px; font-family: Arial, sans-serif;">E. Roux </b><span style="font-size: 13px; font-family: Arial, sans-serif;">(CREATIS, Lyon), </span><b style="font-size: 13px; font-family: Arial, sans-serif;">K. GuÈpiÈ</b><span style="font-size: 13px; font-family: Arial, sans-serif;"> (LM2S, Troyes) et en collaboration avec </span><b style="font-size: 13px; font-family: Arial, sans-serif;">Atys Medical</b><span style="font-size: 13px; font-family: Arial, sans-serif;"> (Soucieu-en-Jarret). L'objectif de son doctorat est de développer un algorithme d'apprentissage profond faiblement supervisé pour la classification et la caractérisation des emboles à partir de signaux Doppler. En étudiant les cadres d'apprentissage faiblement supervisés et en exploitant l'incertitude du modèle, il fournira un aperçu de la cause ou de la nature des emboles en corrélation avec des données hétérogènes telles que la pathologie et/ou le traitement du patient.</span></div><div style="text-align: justify; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 13px;"><br></font></div>
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<div style="text-align: justify;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 13px;"><b>Yamil Vindas </b></font><span style="font-family: Arial, sans-serif; font-size: 13px;">démarre sa thèse de science intitulée "Apprentissage faiblement supervisé pour la caractérisation des emboles avec le suivi Doppler Transcranien (TCD)" sous la supervision de </span><b style="font-size: 13px; font-family: Arial, sans-serif;">P. Delachartre</b><span style="font-size: 13px; font-family: Arial, sans-serif;"> (CREATIS, Lyon), </span><b style="font-size: 13px; font-family: Arial, sans-serif;">E. Roux </b><span style="font-size: 13px; font-family: Arial, sans-serif;">(CREATIS, Lyon), </span><b style="font-size: 13px; font-family: Arial, sans-serif;">K. GuÈpiÈ</b><span style="font-size: 13px; font-family: Arial, sans-serif;"> (LM2S, Troyes) et en collaboration avec </span><b style="font-size: 13px; font-family: Arial, sans-serif;">Atys Medical</b><span style="font-size: 13px; font-family: Arial, sans-serif;"> (Soucieu-en-Jarret). L'objectif de son doctorat est de développer un algorithme d'apprentissage profond faiblement supervisé pour la classification et la caractérisation des emboles à partir de signaux Doppler. En étudiant les cadres d'apprentissage faiblement supervisés et en exploitant l'incertitude du modèle, il fournira un aperçu de la cause ou de la nature des emboles en corrélation avec des données hétérogènes telles que la pathologie et/ou le traitement du patient.</span></p></div><div style="text-align: justify;"><p style="padding: 0px; margin: 0px;"><font face="Arial, sans-serif" style="font-size: 13px;"><br></font></p></div>
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';"><font style="font-size: 13px;"><span style="font-family: Arial, sans-serif;">Contact: </span><font color="#034dff" style="font-family: Arial, sans-serif;"><b><a href="mailto:communication@creatis.insa-lyon.fr">communication@creatis.insa-lyon.fr</a> </b></font><span style="font-family: Arial, sans-serif;"> </span><br></font><div><font face="Arial, sans-serif" style="font-size: 13px;">Laboratoire situé sur le campus LyonTech La Doua: <a href="https://www.google.com/maps/d/viewer?ll=45.782205%2C4.870999&spn=0.008949%2C0.017638&hl=fr&msa=0&z=16&ie=UTF8&mid=1YEoxug8SWBQqfFPC7fOjpe-Ibz8">plan Google-maps</a>, les Hospices Civils de Lyon (HCL), Grenoble (cyclotron), Saint-Etienne (CHU de Saint-Etienne) et le Centre Léon Bérard (CLB).</font></div></div>
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';"><div><font face="Arial, sans-serif" style="font-size: 13px;"><b>Adresse principale:</b></font></div><div><font face="Arial, sans-serif" style="font-size: 13px;">CREATIS Direction - Site INSA</font></div><div><font face="Arial, sans-serif" style="font-size: 13px;">Bâtiment Blaise Pascal (502, 4ème étage)</font></div><div><font face="Arial, sans-serif" style="font-size: 13px;">7 avenue Jean Capelle</font></div><div><font face="Arial, sans-serif" style="font-size: 13px;">69621 Villeurbanne cedex FRANCE</font></div></div>
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<div class="text" style="font-size: 16px; font-family: 'Lucida Grande';"><div><font face="Arial, sans-serif" style="font-size: 13px;"><b>Accueil</b> : Marion LISSAC</font></div><div><font face="Arial, sans-serif" style="font-size: 13px;">Tel. : +33 (0)4 72 43 82 27</font></div><div><font face="Arial, sans-serif" style="font-size: 13px;">Fax : +33 (0)4 72 43 85 26</font></div><div><a href="http://marion.lissac@creatis.insa-lyon.fr"><font face="Arial, sans-serif" style="font-size: 13px;">marion.lissac@creatis.insa-lyon.fr</font></a></div></div>
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<tr><td style="font-size:1px;" width="10"> </td><td align="left" valign="top" class="EQ-06" width="287"><div class="text" style="font-size: 16px; font-family: sans-serif;"><font style="font-size: 13px;"><span style="font-family: Arial, sans-serif;">Contact: </span><font color="#034dff" style="font-family: Arial, sans-serif;"><b><a href="mailto:communication@creatis.insa-lyon.fr">communication@creatis.insa-lyon.fr</a> </b></font><span style="font-family: Arial, sans-serif;"> </span><br></font><div><font face="Arial, sans-serif" style="font-size: 13px;">Laboratoire situé sur le campus LyonTech La Doua: <a href="https://www.google.com/maps/d/viewer?ll=45.782205%2C4.870999&spn=0.008949%2C0.017638&hl=fr&msa=0&z=16&ie=UTF8&mid=1YEoxug8SWBQqfFPC7fOjpe-Ibz8">plan Google-maps</a>, les Hospices Civils de Lyon (HCL), Grenoble (cyclotron), Saint-Etienne (CHU de Saint-Etienne) et le Centre Léon Bérard (CLB).</font></div></div></td><td class="layout-block-horizontal-spacer" width="10"> </td><td width="255" align="left" valign="top"><div class="text" style="font-size: 16px; font-family: sans-serif;"><div><font face="Arial, sans-serif" style="font-size: 13px;"><b>Adresse principale:</b></font></div><div><font face="Arial, sans-serif" style="font-size: 13px;">CREATIS Direction - Site INSA</font></div><div><font face="Arial, sans-serif" style="font-size: 13px;">Bâtiment Blaise Pascal (502, 4ème étage)</font></div><div><font face="Arial, sans-serif" style="font-size: 13px;">7 avenue Jean Capelle</font></div><div><font face="Arial, sans-serif" style="font-size: 13px;">69621 Villeurbanne cedex FRANCE</font></div></div></td><td width="10" class="layout-block-horizontal-spacer"> </td><td width="214" align="left" valign="top" class="EQ-06"><div class="text" style="font-size: 16px; font-family: sans-serif;"><div><font face="Arial, sans-serif" style="font-size: 13px;"><b>Accueil</b> : Marion LISSAC</font></div><div><font face="Arial, sans-serif" style="font-size: 13px;">Tel. : +33 (0)4 72 43 82 27</font></div><div><font face="Arial, sans-serif" style="font-size: 13px;">Fax : +33 (0)4 72 43 85 26</font></div><div><a href="http://marion.lissac@creatis.insa-lyon.fr"><font face="Arial, sans-serif" style="font-size: 13px;">marion.lissac@creatis.insa-lyon.fr</font></a></div></div></td><td style="font-size:1px;" width="10"> </td>
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<tr><td valign="top" class="EQ-05" align="center" width="277"><div class="layout-block-image"><a href="https://www.facebook.com/?stype=lo&jlou=AffZ_FqtMZQBXBixu363GnbNS0W1s1Hi8M2oDC9mv6eBHKpc9rpGSckmAJQzH1QFpeWZNBjmP3mXCAiB2A9nqJXR&smuh=45558&lh=Ac_PailCsRNT4qbA"><img height="56" alt="" src="cid:image-3-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="line-height: 1px; display: block;" class="" width="277"></img><div style="width:0px;height:0px;max-height:0;max-width:0;overflow:hidden;display:none;visibility:hidden;mso-hide:all;"></div></a></div></td><td width="280" valign="top" class="EQ-05" align="center"><div class="layout-block-image"><a href="http://"><img height="57" alt="" src="cid:image-19-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="display: block;" class="" width="280"></img><div style="width:0px;height:0px;max-height:0;max-width:0;overflow:hidden;display:none;visibility:hidden;mso-hide:all;"></div></a></div></td><td width="259" valign="top" class="EQ-05" align="center"><div class="layout-block-image"><a href="https:// www.creatis.insa-lyon.fr"><img height="57" alt="" src="cid:image-20-2D56CA41-E36B-4B60-AD26-BB51B4CA51FA@creatis.insa-lyon.fr" border="0" style="display: block;" class="" width="259"></img><div style="width:0px;height:0px;max-height:0;max-width:0;overflow:hidden;display:none;visibility:hidden;mso-hide:all;"></div></a></div></td>
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<font style="font-size: 13px;"><font face="Arial"><b>CREATIS © 2016 </b> | <a href="https://www.creatis.insa-lyon.fr/mailman/listinfo/newsletter"><b>S’inscrire</b></a><b> / </b><a href="https://www.creatis.insa-lyon.fr/mailman/listinfo/newsletter"><b>Se désincrire</b></a><b> ou</b> envoyer un courriel à: <font color="#034dff"><b><a href="mailto:communication@creatis.insa-lyon.fr">communication@creatis.insa-lyon.fr</a> </b></font></font><span style="font-family: Arial;"> </span></font></div>
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<font style="font-size: 13px;"><font face="Arial"><b>CREATIS © 2016 </b> | <a href="https://www.creatis.insa-lyon.fr/mailman/listinfo/newsletter"><b>S’inscrire</b></a><b> / </b><a href="https://www.creatis.insa-lyon.fr/mailman/listinfo/newsletter"><b>Se désincrire</b></a><b> ou</b> envoyer un courriel à: <font color="#034dff"><b><a href="mailto:communication@creatis.insa-lyon.fr">communication@creatis.insa-lyon.fr</a> </b></font></font><span style="font-family: Arial;"> </span></font></div></td><td style="font-size:1px;" width="10"> </td>
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