Though working at high magnetic field is of particular interest for functional imaging and spectroscopy, challenges linked to relaxation time T1,T2,T2* modification with the field strength have to be addressed to control image contrast and spectrum quality. New acquisition strategies are required, especially in abdominal imaging for which classical imaging sequences do not allow to control image contrast because of the respiratory cycle. Moreover, for anatomical imaging, the SNR gain with the field strength increase is limited by the magnetic losses in living tissues. Thus an interesting alternative could be to perform multiple animal acquisition at the same time using median magnetic field strength with large imaging volume such as clinical systems. Finally, new acquisition strategies coupled to multi-dimensional and/or multi-nuclear spectroscopy are designed. In multidimensional spectroscopy, objectives are either to increase the spatial resolution of the biochemical information or to increase the capability to detect and quantify metabolites present at low concentration and having spectral pattern strongly correlated such as GABA, Glutamate and Glutathion.