02677nas a2200433 4500008004100000022001400041245019700055210006900252260001300321300001100334490000700345520127600352653001001628653000901638653002401647653003201671653002401703653001101727653001101738653004401749653004101793653002601834653003101860653000901891653001601900653002701916653002501943653001901968100001501987700001802002700002102020700002802041700002302069700002302092700001902115700002202134700001902156856006802175 2009 eng d a1522-259400aPhase-contrast magnetic resonance imaging measurements in intracranial aneurysms in vivo of flow patterns, velocity fields, and wall shear stress: comparison with computational fluid dynamics.0 aPhasecontrast magnetic resonance imaging measurements in intracr c2009 Feb a409-170 v613 aEvolution of intracranial aneurysms is known to be related to hemodynamic forces such as wall shear stress (WSS) and maximum shear stress (MSS). Estimation of these parameters can be performed using numerical simulations with computational fluid dynamics (CFD), but can also be directly measured with magnetic resonance imaging (MRI) using a time-dependent 3D phase-contrast sequence with encoding of each of the three components of the velocity vectors (7D-MRV). To study the accuracy of 7D-MRV in estimating these parameters in vivo, in comparison with CFD, 7D-MRV and patient-specific CFD modeling was performed for 3 patients who had intracranial aneurysms. Visual and quantitative analyses of the flow pattern and distribution of velocities, MSS, and WSS were performed using the two techniques. Spearman's coefficients of correlation between the two techniques were 0.56 for the velocity field, 0.48 for MSS, and 0.59 for WSS. Visual analysis and Bland-Altman plots showed good agreement for flow pattern and velocities but large discrepancies for MSS and WSS. These results indicate that 7D-MRV can be used in vivo to measure velocity flow fields and for estimating MSS and WSS. Currently, however, this method cannot accurately quantify the latter two parameters.10aAdult10aAged10aBlood Flow Velocity10aCerebrovascular Circulation10aComputer Simulation10aFemale10aHumans10aImage Interpretation, Computer-Assisted10aImagerie Coeur - Vaisseaux - Poumons10aIntracranial Aneurysm10aMagnetic Resonance Imaging10aMale10aMiddle Aged10aModels, Cardiovascular10aModels, Neurological10aShear Strength1 aBoussel, L1 aRayz, Vitaliy1 aMartin, Alastair1 aAcevedo-Bolton, Gabriel1 aLawton, Michael, T1 aHigashida, Randall1 aSmith, Wade, S1 aYoung, William, L1 aSaloner, David uhttps://www.creatis.insa-lyon.fr/site7/en/publications/BOUS-09b