IDM4: Multiparametric and Multimodal Imaging of skeletal and Myocardial Muscles.

SCIENTIFIC COORDINATOR: Pierre Croisille, PUPH, Head of Pole IMOFON (CHU de Saint-Etienne), Head of the Radiology and Nuclear Medicine Department, Head of Radiology Department at CHUSE.

Project Members: Team 1:  P. Clarysse, N. Duchateau. Team 2: O. Bernard, C. Frindel, T. Grenier, C. Lartizien, R. Prost, M. Sdika. Team 3: P. Delachartre, H. liebgott, F. Varray. Team 5: O. Beuf, P. Croisille, C. Daviller, J. Karkouri, B. Leporq, H. Ratiney, M. Viallon.

I. Socio-economic Context: Coronary heart disease is the leading cause of death in western countries (Hasdai, et al. 2002, Mandelzweig, et al. 2006) and cardiovascular disease accounts for 29% of annual deaths.

II. Link to Equipment and Investments of the Future: Equipex LILI (platform PET-MR platform), LabEX Primes, LabEX Celya.

III. Objectives of the project:  This project aims at achieving technological and methodological developments to enable quantitative multiparametric multi-parameter imaging of the heart and skeletal muscle (PET / MR, but also US / MR), including new theranostic strategies in a Clinical environment. This project will respond to these challenges through a multidisciplinary approach involving physiologists, US and NMR physicists, computer scientists from regional laboratories, as well as French and industrial partners (SIEMENS, OLEA), while strengthening national collaborations And international organizations (Radiology Dept. and CRMBM-CEMEREM, UMR 7339, CNRS Marseille), cardiac imaging experts from European Universities (Lausanne Switzerland), German (Bremen) and American universities (UCLA, Virginia ..).

IV. LThe resources of the projects:

The project received european funding (FEDER), General Council 42 (CG42) and Saint-Etienne Métropole (SME) funding to acquire a 512 Voies VERASONIC power generator. The project has a powerful  clinical research plateform combining a 3T MR magnet equipped with multi-nuclei options, a cardiac and quadriceps ergometer :  Know more...

Obtained funding: RHU MARVELOUS, PHRC MARVEL. FEDER, CG42, SME. Co-financements: CARIM, DIAPASON.

Industrial Partners: OLEA Medical, Siemens, Circle, Carestream, Supersonic Imagine.

Last internal Workshop: September 16th, 2016. Program & presentations for internal use (reserved to the members of the project) : Know more...

V. Current Sub-Projects:

MUST: The MUST project aims to help understand the effect of ultra-endurance on the body and its impact on the muscular and cardiac levels. The team (P. Croisille (Team # 5), O. Beuf (Team # 5), M. Viallon (Team # 5), H. Ratiney (Team#5), T. Grenier (Team # 2) chose to conduct this study at the most extreme Mountain Ultra-Marathon in the world, the "Tor des Géants": 330 km, 24,000 m of positive slope in one go (3x The Everest), in the Valley of Aosta, in Italy and at the foot of Mont Blanc. This race of all the superlatives took place from 7 to 14 September 2014.

TSONOAMI (Imagerie Thérapeutique et infarctus du myocarde à la phase aigüe): Développements Méthodologiques US-MR. M. Viallon (PI,Team #5), P. Croisille (Team #5), L. Petrusca (Team#5), O.Beuf (Team #5), H. Liebgott (Team#3). Il existe un attrait clinique élevé pour les nouvelles technologies théranostiques, non-invasives et capable d’offrir une efficacité au moins comparable à celui des traitements conventionnels (produits thérapeutiques et diagnostiques). Ultrasons focalisés (FUS) a déjà un large impact dans le domaine médical, les différentes applications cliniques étant identifiés à ce jour pour les différents organes (sein, de la prostate, les os, la fibrose bénigne de l'utérus). En raison des défis importants, les applications de FUS pour les thérapies cardiaques n'a pas encore été étudié Il y a un intérêt majeur pour étudier les mécanismes et dans quelle mesure les ultrasons pourraient atténuer la réponse inflammatoire et des lésions myocardiques oedème médiée. Les effets bénéfiques et donc soi-disant effet «sono-cardioprotecteur" des US exploreront le drainage mécanique de massage par une force de rayonnement acoustique (ARF) ou sur l'amélioration de la microcirculation mycoardium ischémique. Il y a aussi un intérêt évident dans le contexte des thérapies guidées par l'image dans les organes mobiles, pour développer l'imagerie hybride US-MR. 

PET-MR Quantitative Perfusion, Team 5 - P. Croisille (PI, Team #5), O.Beuf (Team #5), M. Viallon (Team #5), C. Daviller(Team#5), C. Frindel (Team #2), T. Grenier (Team #2),. (Collaboration: RHU MARVELOUS (OLEA Medical, CARMEN U1060, Cynbiose), Pr Marc Janier(HCL), SIemens). Establishing normal and pathology related Myocardial perfusion standard for improved patient profiling based on newly established Bio-Atlas provided by Advanced Imaging Techniques and Biomarkers. The objective of this collaboration is 1) acquire the methodology to achieve quantitative values of Myocardial Blood Flow using MRI 2) to utilize advanced imaging methods (simultaneous PET-MRI) to investigate absolute perfusion values in humans, and relate them to the cardiovascular metabolic state. Our ultimate goal is to establish a predictive bio-atlas based on advanced imaging biomarkers, and to make available gold standard reference for clinical risk factors investigation, prediction, and improved objective patient management. 

Model-Based Non-Invasive Regional Identification of Myocardial Diseases :  P. Clarysse (PI, Team #1), N. Duchateau (Team #1), P. Croisille (Team #5), M. Viallon (Team #5),  O. Bernard (Team #2), C. Lartizien (Team #2), P. Delachartre (Team #3) in Collaboration with TIMC-Grenoble, ICJ-Lyon, CARMEN-Lyon. The aim of this sub-project is to introduce and validate a new strain based model and methods for the non-invasive regional characterization of the myocardial viability. New concept of myocardial fiber tonicity (MFT) is obtained from the instanciation of a biomechanical parametric finite element (FE) model of the left ventricle (LV), including fiber architecture to patient strain and pressure measurements. The methodology is general, but will be first experimented in cardiac MRI and US, and should provide new biomarkers of regional estimation of the amount of active tension within the myocardium, that may reflect the effective health status of the tissue. Strain measurements will be obtained with state of the art dynamical tagged-MRI (Collab. Prof. Stuber, EPFL).

VI. All Publications from the IDM4 in 2016:

1. Shear-Wave Elastography Assessments of Quadriceps Stiffness Changes prior to, during and after Prolonged Exercise: A Longitudinal Study during an Extreme Mountain Ultra-Marathon. Andonian P, Viallon M, Le Goff C, de Bourguignon C, Tourel C, Morel J, Giardini G, Gergelé L, Millet GP, Croisille P. PLoS One. 2016 Aug 31;11(8):e0161855. doi: 10.1371/journal.pone.0161855. PMID: 27579699

2. Quantifying the effect of tissue deformation on diffusion-weighted MRI: a mathematical model and an efficient simulation framework applied to cardiac diffusion imaging. Mekkaoui I, Moulin K, Croisille P, Pousin J, Viallon MPhys Med Biol. 2016 Aug 7;61(15):5662-86. doi: 10.1088/0031-9155/61/15/5662. PMID:27385441

3. Comparison of Immediate With Delayed Stenting Using the Minimalist Immediate Mechanical Intervention Approach in Acute ST-Segment-Elevation Myocardial Infarction: The MIMI Study. Belle L, Motreff P, Mangin L, Rangé G, Marcaggi X, Marie A, Ferrier N, Dubreuil O, Zemour G, Souteyrand G, Caussin C, Amabile N, Isaaz K, Dauphin R, Koning R, Robin C, Faurie B, Bonello L, Champin S, Delhaye C, Cuilleret F, Mewton N, Genty C, Viallon M, Bosson JL, Croisille P; MIMI Investigators*.Circ Cardiovasc Interv. 2016 Mar;9(3):e003388. doi: 10.1161/CIRCINTERVENTIONS.115.003388. PMID:26957418

4. Image-Based Investigation of Human in Vivo Myofibre Strain. Wang VY, Casta C, Zhu YM, Cowan BR, Croisille P, Young AA, Clarysse P, Nash MP. IEEE Trans Med Imaging. 2016 Nov;35(11):2486-2496. PMID: 27323360

5. Myocardial Extracellular Volume Estimation by CMR Predicts Functional Recovery Following Acute MI. Kidambi A, Motwani M, Uddin A, Ripley DP, McDiarmid AK, Swoboda PP, Broadbent DA, Musa TA, Erhayiem B, Leader J, Croisille P, Clarysse P, Greenwood JP, Plein S. JACC Cardiovasc Imaging. 2016 Oct 18. pii: S1936-878X(16)30645-3. doi: 10.1016/j.jcmg.2016.06.015. [Epub ahead of print] PMID:27771398. Free Article

6. In vivo free-breathing DTI and IVIM of the whole human heart using a real-time slice-followed SE-EPI navigator-based sequence: A reproducibility study in healthy volunteers. Moulin K, Croisille P, Feiweier T, Delattre BM, Wei H, Robert B, Beuf O, Viallon MMagn Reson Med. 2016 Jul;76(1):70-82. doi: 10.1002/mrm.25852. PMID:26301785

7. Effects of glycaemic variability on cardiac remodelling after reperfused myocardial infarction: Evaluation of streptozotocin-induced diabetic Wistar rats using cardiac magnetic resonance imaging. Joubert M, Hardouin J, Legallois D, Blanchart K, Elie N, Nowoczyn M, Croisille P, Coulbault L, Bor-Angelier C, Allouche S, Manrique A. Diabetes Metab. 2016 Mar 10. pii: S1262-3636(16)30012-X. doi: 10.1016/j.diabet.2016.02.002. [Epub ahead of print]. PMID:26971835

8. A new look at left ventricular remodeling definition by cardiac imaging. Bière L, Donal E, Jacquier A, Croisille P, Genée O, Christiaens L, Prunier F, Gueret P, Boyer L, Furber A. Int J Cardiol. 2016 Apr 15;209:17-9. doi: 10.1016/j.ijcard.2016.02.009. No abstract available.  PMID:26878466