Context
It has been shown that regionalized hepatic function may be assessed from SPECT images, and could be useful to adapt patient treatment, both in radiotherapy and surgery. Knowledge of organ function could give to physicians crucial information on the best treatment course. Indeed, risk of hepatic insufficiency is not only related to the volume of remaining liver but also to its quality. Quantitative scintigraphy images could thus be a promising tool. However, absolute quantification in SPECT imaging remains a big challenge in nuclear medicine. Scattering, absorption, patient motion, detector response, limited resolution and reconstruction parameters strongly affect the absolute quantification results. For these reasons, few medical applications currently use them.
Team 4 at CREATIS / Centre Leon Berard is starting a study on the evaluation of the hepatic function prior to surgical hepatectomy based on a series of dynamic planar scintigraphy images and SPECT/CT images. The training student will work with a multidisciplinary team composed of medical physicist, nuclear medicine physician and researchers.
Goal
The goal of this master thesis will be assess a quantification method to evaluate hepatic function from SPECT and planar scintigraphy images.
Task
The training student will have to perform a set of experimental studies and to define a quantification method on a series of 2D and 3D scintigraphy images. Region of interests will have to be defined according to technical possibility and clinical needs. Results should then be validated with experimental and/or simulated data.
Details
- Prerequisites: background in physics, medical physics, SPECT imaging and computer sciences.
- Language: English or French fluent
- Period: according to the master, about 6 months
- Location: Centre Leon Bérard, Lyon, FRANCE, Creatis Team
- Compensation: about 550€/month
Supervisors
- Adrien Halty, PhD student, adrien.halty@creatis.insa-lyon.fr
- Haifa Bahri, nuclear medicine physician, Haifa.Bahri@lyon.unicancer.fr
- Jean-Noel Badel, Medical Physicist, jeannoel.badel@lyon.unicancer.fr
- David Sarrut, directeur de recherche CNRS, david.sarrut@creatis.insa-lyon.fr
- Vanina Isnardi, nuclear medicine physician, vanina.isnardi@lyon.unicancer.fr