Image registration with deep learning
Recrutement en cours/passé: 
Recrutement en cours

Image Registration with Deep Learning

Recalage d'Images Médicales par apprentissage profond

Master II internship - 2022

(version française dans le pdf joint )

Keywords: Medical image registration, Deep Learning

Scientific background

Image registration is a tool to align images, allowing to re-position, re-orientate or even to deform images to replace them in a common coordinate system. This is often an essential preliminary step for the study of brain pathology based on imaging.When the transformation is affine, current registration tools give results that are often satisfactory but but fail in particular when:

  • initialization is bad
  • there are strong imaging artifacts
  • a pathology severely affect the brain appearance
  • only part of the brain is present in the image (cropped image)

Classical registration tools are often based on iterative mathematical optimization approachesbut more and more current methods are based on deep learning approaches [Boveiri].


The objective of the internship is to set up and train a neural network allowingperform linear registration of a brain image to a standard reference space. The main objectiveis to have a very robust estimation but also that the network is lightweight, fast to infer, and also interpretable to be able detect failures.

We can investigate good ways to parameterize the transformation, the equivariant layers [Finzi], capsule network [Sabour, Lensen, Gu].

The linear registration network will be integrated into the brain pre-processing pipeline of theMYRIAD team of CREATIS.Data: several public brain imaging datasets involving different pathologies, acquisition protocols andpathologies, acquisition protocols and modalities are already used in the team and will be used for theinternship. A robust data augmentation procedure will further improve the robustness of our method.


This work will be done in Lyon in collaboration between CREATIS and LIRIS and will be supervised by:- M. Sdika, CREATIS, Myriad team- C. Garcia, LIRIS, Imagine team

Candidate Profile

The recruited candidate will have a background in one of the following areas and good knowledge in the other two:

  • Machine learning (deep learning)
  • Image processing
  • Applied mathematics

He/she should also have strong software development skills and be able to implement the proposedto implement the proposed methods.

Please send your application with CV, cover letter, transcripts, letters of recommendation to michael.sdika[at] and Christophe.garcia[at]


  1. Boveiri et al, Medical Image Registration Using Deep Neural Networks: A Comprehensive Review,
  2. Finzi et al. A Practical Method for Constructing Equivariant Multilayer Perceptrons for Arbitrary Matrix Groups,
  3. Sabour et al, Dynamic Routing Between Capsules,
  4. Lenssen et al, Group Equivariant Capsule Networks, Neurips 2018
  5. Gu J. & Tresp V., Improving the Robustness of Capsule Networks to Image Affine Transformations, CVPR 2020.