Peter Coveney et Nour Shublaq from University College London, With the advent of whole human genome sequencing in minutes and the costs now counted in hundreds of pounds, the potential of the Human Genome Project can finally begin to be realised. At the same time, large initiatives such as the Virtual Physiological Human are addressing pathologies at a phenotypical level. The challenges in front of us to meld and convert these rapidly developing scientific capabilities into useful medical and clinical information remain very substantial -- from the secure management of the clinical derived data across hospital-university interfaces, via the development of large scale data integration warehouses, and back into clinical decision support systems. There are also fundamental issues associated with how we treat the genotype-phenotype relationship. We will survey the state of the art and highlight the problems that currently limit our ability to implement the vision for personalised medicine in its full form.