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MRI pulse design with numerical optimal control algorithms

Selective excitation

Iterative optimal control algorithms such as GRAPE can be applied to typical MRI applications such as RF pulse design. A simple example is the design of spatially selective RF excitation with linear phase distribution.

Slice profile Phase distribution

Phase control

Optimal control pulses can also be applied to more sophisticated applications to encode various tissue characteristics into the NMR signal. As an example on Magnetic Resonance Elastography, tissue motion can be encoding in the phase of the NMR signal and used to visualize the propagation of a shear wave into the imaged tissue.

Magn Phase

B1-robust Energy Efficient Excientation Pulses (BEEEP)

An alternative to adiabatic excitation is proposed in presence of large variations of B1 amplitudes. Using a regularized approaches, B1-robust pulses can be obtained. They offer a significant advantage in terms of both required peak amplitude and energy deposition over adiabatic pulses (BIR-4 in this example).

Magn Energy

Contrast optimization

Optimal control can be also used at a larger scale to optimize MR preparation for contrast optimization, based on the tissue relaxation time differences. Interesting results have been obtained in the contaxt of short-T2 imaging (thalamus and corpus callosum in the example below). Significant benefit is obtained in terms of preparation time and SNR when compared to inversion recovery. Clinical applications are being currently investigated.

RARE RARE

MRI super-resolution reconstruction

To be completed…

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CPE Lyon (~300h/year)

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