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Research topics

MRI pulse design with numerical optimal control algorithms

Contrast optimization

Contrast preparation sequences are optimized using optimal control theory, based on the tissue relaxation time differences, in order to obtain a specific contrast. Interesting results have been obtained in the contaxt of short-T2 imaging (thalamus and corpus callosum in the example below). Significant benefit is obtained in terms of preparation time and SNR when compared to inversion recovery. Clinical applications are being currently investigated.


Phase control

Optimal control pulses can be used to encode various tissue characteristics into the NMR signal. As an example on Magnetic Resonance Elastography, tissue motion can be encoding in the phase of the NMR signal and used to visualize the propagation of a shear wave into the imaged tissue.

Magn Phase

B1-robust Energy Efficient Excientation Pulses (BEEEP)

An alternative to adiabatic excitation is proposed in presence of large variations of B1 amplitudes. Using a regularized optimal control algorithm, B1-robust pulses are obtained, offering a significant advantage in terms of both required peak amplitude and energy deposition over adiabatic pulses (BIR-4 in this example).

Magn Energy

MRI super-resolution reconstruction

To be completed…


PhD students

Master students



CPE Lyon (~300h/year)